ArticleAJNR. American journal of neuroradiology2025
Arterial Spin-Labeling MRI Identifies Abnormal Perfusion Metric at the Gray Matter/CSF Interface in Cerebral Small Vessel Disease.
Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Arterial Spin-Labeling MRI at the Cortical-CSF Interface: A Novel Biomarker in Alzheimer Disease.Annals of clinical and translational neurology · 2026Article
- Arterial spin labeling MRI in CADASIL: Implications for cerebral small vessel disease and therapeutic trials.Cerebral circulation - cognition and behavior · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeCerebral small vessel disease (SVD) is a common cause of stroke and cognitive decline. SVD is characterized by white matter hyperintensities (WMH) and dilated perivascular spaces (PVS). While WMH can be associated with reduced CBF and glymphatic clearance, current clinical and radiologic assessments of these associations remain controversial and mostly qualitative. We aim to identify if arterial spin-labeling (ASL)-based CBF differences, particularly in the cortical surface at the GM/CSF interface, correlate with SVD severity. MATERIALS AND
methodsWe performed a retrospective cohort study of healthy controls with normal cognition who underwent a brain MRI as part of our university's Alzheimer Disease Research Center (ADRC) and an
resultsThirty-two patients met the inclusion criteria (
conclusionsnGCI, a novel perfusion metric that may capture features of perfusion at the GM-CSF boundary, was strongly correlated with WMH and PVS severity. Further, longitudinal studies are required to determine the potential role of nGCI as a predictive marker of SVD progression.
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