ArticleAnimal bioscience2025
Spray-dried porcine plasma improves piglets' performance and modulates gut immune-related genes in the first week post-weaning.
Article in Animal bioscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Impact of zinc oxide on gut health, immunity, and growth in weaned piglets: exploring potential modes of action.Frontiers in veterinary science · 2025Article
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Authors and funding
8 authors.
Funding
Abstract
objectiveThis study aimed to explore the effects of spray-dried porcine plasma (SDPP) in pre-starter feed of piglets on performance, fecal consistency, gut integrity biomarkers, and gene expression patterns related to intestinal function.
methodsNinety piglets (18 pens; 5 pigs/pen; 8.16±1.29 kg initial body weight) were offered pre-starter feed with either soy protein concentrate (control) or SDPP for 14 d postweaning, and a common commercial starter feed between 14 and 35 d. Pigs' performance was recorded at 0, 7, 14 and 35 d of trial and their fecal consistency was assessed on the first 2 weeks. At 7 d, one piglet per pen (18 in total) was sampled for blood, intestinal mucosa, and bile. Blood serum calprotectin and citrulline and bile sIgA were quantified with ELISA, and gene expression in the mucosa from ileum, jejunum, and caecum was analyzed with high-throughput microfluidic technology.
resultsRelative to control, SDPP improved feed intake (215 vs 280 g/d; p<0.05), weight gain (133 vs. 205 g/d; p<0.05) and gain-to-feed ratio (0.61 vs. 0.74; p<0.05) between d 0 to 7. Serum calprotectin and citrulline, and bile sIgA at d 7 were not affected. Piglets fed SDPP had higher expressions of IL-1β (p = 0.033) in jejunal mucosa, and of IL-1β (p = 0.018), IL-8/CXCL8 (p = 0.010), GBP1 (p = 0.014) and TGF-β1 (p = 0.015) in ileal mucosa, at 7 d post-weaning. No effects on fecal scores were observed.
conclusionIt is concluded that the administration of SDPP during the pre-starter phase improves piglet's performance during the first week post-weaning. These SDPP associated benefits appear to have been achieved through the modulation of gut homeostasis, potentially involving the regulation of inflammatory factors in the small intestinal mucosa.
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