Evidence map›Paper›PMID 40506029›Full record

Observational studyCancer research and treatment2026

Secondary Cancer Risk in Breast Cancer with and without Radiotherapy: The Observational Health Data Sciences and Informatics (OHDSI) Cohort Study.

Seok Kim, Dachung Boo, Sooyoung Yoo, Borham Kim, Kyubo Kim, Kwangsoo Kim, Eunhye Song, Junmo Kim, Hyun Gee Ryoo, Jin Chul Paeng and 5 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Cancer research and treatment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Seok KimOffice of eHealth Research and Business, Seoul National University Bundang Hospital, Seongnam, Korea.
Dachung BooDepartment of Biomedical Systems Informatics, Yonsei University College of Medicine Institute for Innovation in Digital Healthcare, Seoul, Korea.
Sooyoung YooOffice of eHealth Research and Business, Seoul National University Bundang Hospital, Seongnam, Korea.
Borham KimOffice of eHealth Research and Business, Seoul National University Bundang Hospital, Seongnam, Korea.
Kyubo KimDepartment of Radiation Oncology, Seoul National University Bundang Hospital, Seongnam, Korea.
Kwangsoo KimDepartment of Transdisciplinary Medicine, Seoul National University Hospital, Seoul, Korea.
Eunhye SongDepartment of Data Science Research, Innovative Medical Technology Research Institute, Seoul National University Hospital, Seoul, Korea.
Junmo KimInterdisciplinary Program in Bioengineering, Seoul National University, Seoul, Korea.
Hyun Gee RyooDepartment of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea.
Jin Chul PaengDepartment of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea.
In Young ChoiDepartment of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
SooJeong KoDepartment of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Ie Ryung YooDivision of Nuclear Medicine, Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Rae Woong ParkDepartment of Biomedical Informatics, Ajou University School of Medicine, Suwon, Korea.
Ho-Young LeeOffice of eHealth Research and Business, Seoul National University Bundang Hospital, Seongnam, Korea.

Funding

Korea Health Industry Development InstituteMinistry of Health and Welfare HI19C0378Ministry of Health and Welfare RS-2022-KH125200Ministry of Trade, Industry and Energy 20004927
6 · The paper itself

Abstract

purposeRadiotherapy is used to reduce the risk of breast cancer recurrence after surgery, but it is a potential cause of secondary cancer. We validated the risk of secondary cancer in primary breast cancer who received radiotherapy compared with those who did not from a matched cohort using a large-scale observational study of the Observational Health Data Sciences and Informatics (OHDSI) data network. MATERIALS AND

methodsA retrospective comparative cohort study using propensity score-matched cohorts was performed using two Observational Medical Outcome Partnership common data model databases, from tertiary general hospitals in South Korea. Among female patients who underwent surgery after the diagnosis of breast cancer, the risk of secondary primary malignant occurrence after 1:1 matching was analyzed.

resultsAmong 27,078 patients with breast cancer, there was no significant difference in the risk of secondary cancer following radiotherapy in 4,426 patients after 1:1 propensity-score matching. Further, there were no significant differences in the sensitivity analysis according to age, latency period, and number of radiation treatments.

conclusionThere was no difference in the risk of secondary cancer in the patients diagnosed with breast cancer depending on whether or not radiotherapy was performed after surgery. In the future, it is necessary to analyze including data generated during cancer treatment.

Indexed as

Breast NeoplasmsNeoplasms, Radiation-InducedNeoplasms, Second PrimaryAdultAgedFemaleHumansMiddle AgedPropensity ScoreRepublic of KoreaRetrospective StudiesRisk FactorsBreast neoplasmsCommon data modelPropensity-score matchingRadiotherapySecondary primary malignant

Identifiers

PMID40506029
PMCPMC13093026

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.