ReviewBiological psychiatry2025
Biological Mechanisms of Sleep/Wake-Related Function.
Review in Biological psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Measuring the Impacts of Urbanicity and Different Exposome Factors on Human Brain through Exposure Network Mapping.Neuroscience bulletin · 2026Article
- Sleep and Mental Health: Unveiling the Critical Role of Sleep in Brain Function and Psychiatric Disorders.Biological psychiatry · 2025Article
- Progress in Research on the Mechanism of GABA in Improving Sleep.Foods (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Animals oscillate between sleep and wake periods characterized by foraging for food and avoiding danger, with a relatively high level of arousal during waking and by a relative absence of movement and decreased level of arousal during sleep. In the brain, at the cellular level, waking involves energy-efficient oxidative phosphorylation that can conserve metabolites, whereas during sleep, energy and metabolites are utilized to support protein anabolism and turnover. At the intercellular level, this bias in metabolism can facilitate sleep-dependent glutamate synaptic reorganization by downscaling synaptic strength and enhancement of metaplastic potentiating plasticity. The dual focus of this review is on the molecules and genetics in the intracellular pathways that control the functionally permissive state of sleep and the functional outcomes of sleep. These sleep-related functional outcomes require MEF2c-dependent transcriptional changes targeting genes that regulate glutamate synapses. The same genes are enriched for known risk factor genes for autism spectrum disorder, consistent with an interaction of sleep and autism.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.