Evidence map›Paper›PMID 40505995›Full record

ArticleJournal of pain and symptom management2025

Cancer Prognostic Awareness: Relations to Patient and Caregiver Quality of Life and Care Preferences.

Ellen Krueger, Catherine E Mosher, Ashley Lewson, Susan E Hickman, Wei Wu, Holly G Prigerson

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Article in Journal of pain and symptom management, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Ellen KruegerDivision of Neuropsychology, Department of Neurology (E.K.), Medical College of Wisconsin, Milwaukee, Wisconsin, USA. Electronic address: elkrueger@mcw.edu.
Catherine E MosherDepartment of Psychology (C.E.M., A.L., W.W.), Indiana University Indianapolis, Indianapolis, Indiana, USA.
Ashley LewsonDepartment of Psychology (C.E.M., A.L., W.W.), Indiana University Indianapolis, Indianapolis, Indiana, USA.
Susan E HickmanDepartment of Community and Health Systems, Indiana University School of Nursing (S.E.H.), Indianapolis, Indiana, USA; Indiana University Center for Aging Research (S.E.H.), Regenstrief Institute, Indianapolis, Indiana, USA; Department of Medicine, Indiana University School of Medicine (S.E.H.), Indianapolis, Indiana, USA.
Wei WuDepartment of Psychology (C.E.M., A.L., W.W.), Indiana University Indianapolis, Indianapolis, Indiana, USA.
Holly G PrigersonCornell Center for Research on End-of-Life Care (H.G.P.), Weill Cornell Medicine, New York, New York, USA; Department of Radiology (H.G.P.), Weill Cornell Medicine, New York, New York, USA; Department of Medicine (H.G.P.), Weill Cornell Medicine, New York, New York, USA.

Funding

Psychosocial Approaches to Better Understanding & End-Stage Cancer Care (PROTECT)R35CA197730 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Holly Gwen Prigerson · 2015 to 2026
$11.2M
Quality of Death: Ethnic and Psychosocial InfluencesR01CA106370 · NCI · YALE UNIVERSITY · PI PRIGERSON, HOLLY GWEN · 2004 to 2015
$4.1M
NCI NIH HHS R01 CA106370NCI NIH HHS R35 CA197730
6 · The paper itself

Abstract

contextPatients who are prognostically aware are more likely to receive end-of-life care consistent with their values. However, prognostic awareness has shown mixed associations with patients' quality-of-life (QoL) outcomes. Theory suggests that acceptance of cancer may moderate relationships between prognostic awareness and outcomes of QoL and end-of-life treatment preferences. Patients' degree of prognostic awareness and illness acceptance may also impact their family caregivers' QoL and end-of-life treatment preferences for the patient.

objectivesTo examine the potential moderating role of patient acceptance of cancer in the relationships between patient prognostic awareness and both patient and caregiver QoL and end-of-life treatment preferences.

methodsA cross-sectional, secondary analysis was conducted using data from patients with advanced cancer (n = 243) and their caregivers (n = 87) in the multi-institutional Coping with Cancer-II cohort study. Patient physical, psychological, and existential QoL were examined in a moderation path analysis. Caregiver physical and psychological QoL were examined in separate linear regression analyses. Patient and caregiver end-of-life treatment preferences were examined in multiple logistic regression moderation models.

resultsNo significant moderations were found. Greater patient illness acceptance was associated with better patient QoL outcomes and caregiver psychological QoL but was unrelated to end-of-life treatment preferences. Greater patient prognostic awareness was associated with worse patient physical QoL and both patients' and caregivers' preference for comfort care.

conclusionIncreasing patients' prognostic awareness and cancer acceptance may improve values-consistent end-of-life care and patient and caregiver QoL outcomes. Findings support timely conversations to promote prognostic awareness and further testing of acceptance-based interventions in advanced cancer.

Indexed as

CaregiversHealth Knowledge, Attitudes, PracticeNeoplasmsPatient PreferenceQuality of LifeAdultAgedAged, 80 and overAwarenessCross-Sectional StudiesFemaleHumansMaleMiddle AgedPrognosisTerminal CareAdvanced cancercaregiverend-of-life treatment preferenceillness acceptanceprognostic awarenessquality of life

Identifiers

PMID40505995
PMCPMC12455738

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.