Evidence map›Paper›PMID 40505836›Full record

ArticleThe Journal of allergy and clinical immunology2025

Mouse T

Kaitlyn E Bunn, Brenna G Giese-Byrne, Alexander M Blatt, Dawn C Newcomb, Heather H Pua

Abstract read
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Article in The Journal of allergy and clinical immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
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  5. Review
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Kaitlyn E BunnDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tenn.
Brenna G Giese-ByrneDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tenn.
Alexander M BlattDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tenn.
Dawn C NewcombDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tenn; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, Tenn; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, Tenn.
Heather H PuaDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tenn; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, Tenn; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, Tenn; Vanderbilt Center for Extracellular Vesicle Research, Vanderbilt University, Nashville, Tenn. Electronic address: heather.pua@vumc.org.

Funding

Extracellular RNA Communication in Lung InflammationDP2HL152426 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PUA, HEATHER H · 2019 to 2019
$2.5M
NHLBI NIH HHS DP2 HL152426
6 · The paper itself

Abstract

backgroundExtracellular vesicles (EVs) mediate intercellular communication during immune responses. EVs are abundant in respiratory biofluids, and the composition of EVs in the lung changes during inflammation.

objectiveWe sought to quantify the contribution of T cells to airway EVs in eosinophilic lung inflammation and ascertain their function during a type 2 inflammatory response.

methodsGenetic membrane tagging was combined with single vesicle flow cytometry to quantify T-cell EVs in the airways of mice challenged with ovalbumin or house dust mite. EVs were purified from mouse T

resultsT-cell EVs are increased in the airways of mice after ovalbumin- or house dust mite-induced inflammation. EVs secreted by T

conclusionsT

Indexed as

EosinophilsExtracellular VesiclesInterleukin-3Th2 CellsAnimalsCell SurvivalFemaleMiceMice, Inbred C57BLOvalbuminPulmonary EosinophiliaPyroglyphidaeInterleukin-3OvalbuminallergicasthmaeosinophilsExtracellular vesiclesIL-3lungT(H)2 cellstype 2 inflammation

Identifiers

PMID40505836
PMCPMC13318181

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.