ArticleExperimental eye research2025
In vivo changes in the gradient of refractive index distribution in the accommodating human lens.
Article in Experimental eye research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Presbyopia: Current Perspectives and Prospects for Patients.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Review
- Development of a multi-parametric MRI platform to evaluate steady-state water content and optical properties in multiple ex vivo bovine lens.Experimental eye research · 2026Article
- Modulation of the lens water content changes the stiffness of theFrontiers in ophthalmology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Previously, we observed that accommodative rounding of the young human lens was accompanied by a redistribution in its internal free water content that resulted in a more linear water gradient across the anterior region of the lens. We hypothesised that this would produce a smoother gradient of refractive index (GRIN) which would, in turn, increase the internal lens refractive contribution to lens power during accommodation. However, in vivo studies of the human lens GRIN changes during accommodation remain limited and report mixed findings. To gain further insight into this, we employed our established magnetic resonance imaging (MRI) protocols to measure the changes in lens geometry and GRIN for 10 young (aged 20-27 years) and 14 middle-aged (aged 48-55 years) adults under a 3 Dioptre (D) accommodative stimulus. The MRI-derived lens measurements were then modelled in Zemax OpticStudio software to quantify the refractive contribution of the GRIN changes to the overall lens power increase during accommodation. In young participants, we observed a significant smoothing of the anterior GRIN, which contributed some 1.47-1.59 D of the total 3.04 D increase in lens power under the 3 D accommodative stimulus. In contrast, presbyopic lenses showed no significant changes in geometry or GRIN, culminating in only a total 0.62 D increase in lens power. These findings support the presence of an intracapsular mechanism of accommodation (ICMA) and highlight the need to consider internal lens optics alongside mechanical properties when developing new treatments for presbyopia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.