Evidence map›Paper›PMID 40505593›Full record

Trial reportJournal of psychosomatic research2025

Psychological mechanisms of prenatal mindfulness training on antenatal blood pressure reduction: A pilot study.

Margaret H Bublitz, Micheline Anderson, Ghada Bourjeily, Elena Salmoirago-Blotcher

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of psychosomatic research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03679117 (Prenatal Mindfulness Training for Pregnant Women at Risk for Hypertension), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03679117 nacompletednot on this map

Prenatal Mindfulness Training for Pregnant Women at Risk for Hypertension

TypeinterventionalSponsorLifespanRan2019 to 2022Enrolled30ConditionsHypertension in PregnancyArmsMindfulness Training
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Margaret H BublitzWomen's Medicine Collaborative at The Miriam Hospital, Providence, RI, USA; Department of Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA; Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, USA; Department of Obstetrics & Gynecology, Warren Alpert Medical School of Brown University, Providence, RI, USA. Electronic address: margaret_bublitz@brown.edu.
Micheline AndersonWomen's Medicine Collaborative at The Miriam Hospital, Providence, RI, USA; Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, USA.
Ghada BourjeilyWomen's Medicine Collaborative at The Miriam Hospital, Providence, RI, USA; Department of Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA.
Elena Salmoirago-BlotcherDepartment of Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA; Department of Epidemiology, Warren Alpert Medical School of Brown University, Providence, RI, USA.

Funding

Uncoupling of IL-1 beta and VEGF-A Crosstalk Contributes to Impaired Arteriogenesis Response to Ischemia in Chronic Diabetes MellitusP20GM103652 · NIGMS · OCEAN STATE RESEARCH INSTITUTE, INC. · PI HARRINGTON, ELIZABETH O · 2013 to 2022
$21.3M
Pilot Projects ProgramP30GM149398 · NIGMS · OCEAN STATE RESEARCH INSTITUTE, INC. · PI Peng Zhang · 2023 to 2026
$5.5M
Mechanisms of mindfulness training to prevent hypertensive disorders of pregnancyR01HL157288 · NHLBI · MIRIAM HOSPITAL · PI BUBLITZ, MARGARET · 2021 to 2025
$2.8M
NHLBI NIH HHS R01 HL157288NIGMS NIH HHS P20 GM103652NIGMS NIH HHS P30 GM149398
6 · The paper itself

Abstract

backgroundHypertensive disorders of pregnancy (HDP) are a significant cause of perinatal morbidity and mortality. Mindfulness training (MT) shows promise for reducing blood pressure during pregnancy; however, the underlying mechanisms by which MT exerts this effect remain unclear.

objectivesThe objectives of this pilot randomized clinical trial were to study psychological mechanisms through which MT may reduce blood pressure in pregnancy. STUDY

designPregnant participants were randomized to an 8-week phone-delivered mindfulness intervention or usual care. Antenatal blood pressure values were extracted from medical records before and after the intervention to examine change in blood pressure. Participants also completed self-report measures of depression, anxiety, perceived stress, and mindfulness before and after the intervention.

resultsTwenty-nine participants were randomized to phone-based MT (N = 15) or usual care (N = 14). Blood pressure significantly decreased across participation among those randomized to MT vs. usual care (systolic blood pressure (F = 5.093, p = .035); diastolic blood pressure (F = 9.689, p = .005)). Reductions in perceived stress mediated the relationship between mindfulness training and decreases in systolic-but not diastolic-maternal blood pressure.

conclusionsFindings from this pilot trial suggest that reductions in perceived stress may underlie the effect of prenatal mindfulness training on lowering maternal systolic blood pressure. CLINICAL

trial registrationThe ClinicalTrials.gov identifier is NCT03679117.

Indexed as

Blood PressureHypertension, Pregnancy-InducedMindfulnessPrenatal CareStress, PsychologicalAdultAnxietyDepressionFemaleHumansPilot ProjectsPregnancyTreatment OutcomeBlood pressureClinical trialMindfulnessPregnancyStress

Identifiers

PMID40505593
PMCPMC13439572

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.