ReviewBiomaterials2026
Soft tissue integration around dental implants: A pressing priority.
Review in Biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- ROS-responsive HBioactive materials · 2027Article
- Dual-Targeted Biomimetic MoSeAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Review
- Biocompatible Germanium-Enriched Nanocomposite Coatings on Titanium Designed Toward Preventing Early Inflammation and Promoting Osteogenic Differentiation.Journal of functional biomaterials · 2026Article
- Z-classification: an anatomy-based ridge-sinus-zygoma classification and decision funnel for zygomatic implantology.Clinical oral investigations · 2026Review
- Oral Motion-Powered Smart Dental Implant Abutment for In Situ Antibacterial and Cell Adhesion Through Piezoelectric Effect.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Cellular Responses at the Zirconia Dental Implant Interface: A Comprehensive Review.Journal of functional biomaterials · 2026Review
- Dental implant nanotopography for peri-implant tissue stability: soft-tissue sealing, innate immune calibration, and active biointerface regulation.International journal of implant dentistry · 2026Review
- Interface Wettability Transition-Driven Drug Release and Dual-Phase Functionalization in Implant Abutment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Quantitative analysis of peri-implant collagen fiber orientation around external hexagon and Morse taper implant connections: A dog model study.Journal of clinical and experimental dentistry · 2026Review
- Research Progress and Translational Perspectives of Piezoelectric Materials in Dental Implant Surface Engineering.Journal of functional biomaterials · 2026Review
- Nano-Engineered Titanium Implants Loaded With Gingival Fibroblasts-Derived Microvesicles Enhance Early Osseointegration And Soft Tissue Attachment In Vivo.Advanced healthcare materials · 2026Article
- Sustainable nanomaterials for precision dental medicine: green synthesis, therapeutic applications, and future directions.Journal of nanobiotechnology · 2026Review
- Impact of Zirconia and Titanium Implant Surfaces of Different Roughness on Oral Epithelial Cells.Dentistry journal · 2026Article
- Surface Modification of Cranioplasty Implants to Reduce Postoperative Cerebrospinal Fluid Collection: A Preliminary Clinical Study.Korean journal of neurotrauma · 2026Article
- Laminin functionalization of zirconia abutments modulates early oral biofilm formation in vitro.Journal of oral microbiology · 2026Article
- Keratinized Mucosa Width and Peri-Implant Health: Clinical Associations to Inform Soft Tissue Evaluation.International journal of dentistry · 2026Article
- Polarity of hemidesmosome instructive light-curable biosealants guides nascent extracellular matrix for favorable epithelial interactions.Materials today. Bio · 2025Article
- Inducing macrophage M2-Type polarization via anodized anisotropic TiOBMC oral health · 2025Article
- 3D Printing of Shape Memory Resin for Orthodontic Aligners with Green Synthesized Antimicrobial ZnO Nanoparticles Coatings: Toward Bioactive Devices.Bioengineering (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
While osseointegration has traditionally been the focal point of dental implant design, recent research highlights the equally crucial role of establishing a resilient and biologically integrated soft tissue seal for long-term implant success. This review critically examines recent advances (primarily from the past five years) that elucidate the molecular, cellular, and materials science strategies essential for enhancing peri-implant soft tissue integration. Key factors include precisely engineered surface topographies at micro- and nanoscale levels, surface chemical modifications that enhance wettability and protein adsorption, and biomimetic coatings incorporating extracellular matrix-derived peptides, chemokines, and growth factors. Recent studies underscore the impact of laser micro- and nano-texturing, plasma treatments, and biofunctionalization in modulating fibroblast and epithelial cell behaviors, accelerating tissue attachment, and mitigating early inflammatory responses. Emerging implant-abutment designs, such as platform switching and transmucosal zirconia abutments, demonstrate improved soft tissue stability and reduce crestal bone loss. Additionally, the immunomodulatory potential of next-generation materials offers promising avenues for directing macrophage polarization and enhancing wound resolution. Collectively, this review synthesizes the latest evidence on material-driven and biological strategies for engineering a stable soft tissue interface. It provides a translational roadmap for the development of implant systems optimized for long-term soft tissue health, addressing a critical unmet need in dental implantology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.