Evidence map›Paper›PMID 40505183›Full record

ArticleGynecologic oncology2025

No increase in chronic kidney disease after postoperative acute kidney injury in gynecologic oncologic ERAS surgery.

Sarah P Huepenbecker, Maria D Iniesta, Mark F Munsell, Sreedhar Mandayam, Praveen Ratanasrimetha, Katherine Cain, Gabe Mena, Javier Lasala, Pedro Ramirez, Larissa Meyer

Abstract readComparative Study
In one paragraph

Article in Gynecologic oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sarah P HuepenbeckerThe University of Texas MD Anderson Cancer Center, Department of Gynecologic Oncology and Reproductive Medicine, Houston, TX, United States of America. Electronic address: sarah.huepenbecker@sluhn.org.
Maria D IniestaThe University of Texas MD Anderson Cancer Center, Department of Gynecologic Oncology and Reproductive Medicine, Houston, TX, United States of America.
Mark F MunsellThe University of Texas MD Anderson Cancer Center, Department of Biostatistics, Houston, TX, United States of America.
Sreedhar MandayamThe University of Texas MD Anderson Cancer Center, Department of Nephrology, Houston, TX, United States of America.
Praveen RatanasrimethaThe University of Texas MD Anderson Cancer Center, Department of Nephrology, Houston, TX, United States of America.
Katherine CainThe University of Texas MD Anderson Cancer Center, Department of Pharmacy Clinical Programs, Houston, TX, United States of America.
Gabe MenaThe University of Texas MD Anderson Cancer Center, Department of Anesthesiology and Perioperative Medicine, Houston, TX, United States of America.
Javier LasalaThe University of Texas MD Anderson Cancer Center, Department of Anesthesiology and Perioperative Medicine, Houston, TX, United States of America.
Pedro RamirezHouston Methodist Hospital, Department of Obstetrics and Gynecology, Houston, TX, United States of America.
Larissa MeyerThe University of Texas MD Anderson Cancer Center, Department of Gynecologic Oncology and Reproductive Medicine, Houston, TX, United States of America.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DIANE BODURKA · 1985 to 2026
$290.8M
Training of Academic Gynecologic OncologistsT32CA101642 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI ANIL K SOOD, Kathleen Schmeler · 2005 to 2026
$9.2M
U.T. M. D. Anderson Cancer Center SPORE in Ovarian CancerP50CA217685 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SOOD, ANIL K · 2017 to 2021
$7.9M
NCI NIH HHS P30 CA016672NCI NIH HHS P50 CA217685NCI NIH HHS T32 CA101642
6 · The paper itself

Abstract

objectiveTo compare development of long-term chronic kidney disease (CKD) and cardiac conditions postoperatively among patients who did and did not develop acute kidney injury (AKI) after open ERAS surgery for gynecologic malignancy.

methodsWe compared patients with and without postoperative AKI within 30 days of open surgery for gynecologic malignancies using ERAS protocols from March 2016-December 2018 at a single academic institution. We estimated 36-month cumulative incidence of renal and cardiac conditions for each cohort. We compared cohorts using comparative statistics and performed univariate and multivariate analyses on time to development of CKD.

resultsAmong 378 patients, 51 (13.5 %) developed postoperative AKI. Over a median follow-up of 19.4 months (range 0.1-59.2 months), patients with AKI were twice as likely to develop CKD (p < 0.001). There was no difference in development of any cardiac condition (p = 0.74) between patients with and without AKI. The cumulative incidence of CKD at 36 months was 23.4 %. On univariate analysis, patients with AKI were more likely to develop CKD (HR = 2.17, 95 % CI 1.22-3.84) but AKI was not significantly associated with CKD on multivariate analysis. Older age (p < 0.001), body mass index ≥30 kg/m

conclusionWe found no differences in long-term renal or cardiac conditions between patients with and without postoperative AKI after open ERAS surgery for gynecologic malignancies. Factors other than postoperative AKI appear more important in CKD development in patients with gynecologic cancers.

Indexed as

Acute Kidney InjuryEnhanced Recovery After SurgeryGenital Neoplasms, FemaleGynecologic Surgical ProceduresPostoperative ComplicationsRenal Insufficiency, ChronicAdultAgedAged, 80 and overFemaleHeart DiseasesHumansIncidenceMiddle AgedMultivariate AnalysisRetrospective StudiesAcute kidney injuryChronic kidney diseaseEnhanced recovery after surgeryGynecologic cancerOpen abdominal surgerySurgical outcomes

Identifiers

PMID40505183
PMCPMC12302991

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.