Evidence map›Paper›PMID 40505053›Full record

ArticleJournal of the American Chemical Society2025

Self-Assembly of Alkynylplatinum(II) Complexes for Sialic Acid Detection and Differentiation of Cancer Cells from Normal Cells.

Jungu Guo, Eric Ka-Ho Wong, Guang-Xi Xu, Angela Sin-Yee Law, Michael Ho-Yeung Chan, Jonathan Lam, Ziyong Chen, Kenneth Kam-Wing Lo, Vivian Wing-Wah Yam

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jungu GuoInstitute of Molecular Functional Materials and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong 999077, People's Republic of China.
Eric Ka-Ho WongInstitute of Molecular Functional Materials and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong 999077, People's Republic of China.ORCID 0000-0001-6652-3259
Guang-Xi XuDepartment of Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong 999077, People's Republic of China.
Angela Sin-Yee LawInstitute of Molecular Functional Materials and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong 999077, People's Republic of China.
Michael Ho-Yeung ChanInstitute of Molecular Functional Materials and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong 999077, People's Republic of China.ORCID 0000-0003-1961-497X
Jonathan LamInstitute of Molecular Functional Materials and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong 999077, People's Republic of China.
Ziyong ChenInstitute of Molecular Functional Materials and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong 999077, People's Republic of China.ORCID 0000-0002-7407-0840
Kenneth Kam-Wing LoDepartment of Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong 999077, People's Republic of China.ORCID 0000-0002-2470-5916
Vivian Wing-Wah YamInstitute of Molecular Functional Materials and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong 999077, People's Republic of China.ORCID 0000-0001-8349-4429

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of platinum(II) complexes incorporating a histidine moiety and/or positively charged group has been designed and synthesized to explore the specific binding between platinum(II) complexes and the analyte and their sensing ability. The specific hydrogen bonding between the histidine moiety and sialic acids, and the electrostatic interaction between the positively charged trimethylammonium group of the platinum(II) complexes and negatively charged carboxylate groups of sialic acids have been found to enhance the binding affinity. The supramolecular assembly of platinum(II) complexes upon binding to sialic acids induces remarkable luminescence changes due to noncovalent Pt(II)

Indexed as

AlkynesN-Acetylneuraminic AcidOrganoplatinum CompoundsSialic AcidsCell DifferentiationCell Line, TumorHumansMolecular StructureAlkynesN-Acetylneuraminic AcidOrganoplatinum CompoundsSialic Acids

Identifiers

PMID40505053
PMCPMC12203603

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.