ArticleScience (New York, N.Y.)2025
Carbonyl-to-sulfur swap enabled by sequential double carbon-carbon bond activation.
Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Lignin-degrading-inspired dehydrogenative photocatalysis via reductive quenching of donor-acceptor covalent organic framework.Science advances · 2026Article
- Direct Access to the SimplestJACS Au · 2026Article
- Formal nitrogen-to-carbon replacement in isoindolines to form indenesChemical science · 2026Article
- Shape-Conserving Atom Replacements.Chemical reviews · 2026Review
- Carbocycle editing of ketones proceeds via a radical-mediated bidirectional C-C bond cleavage/coupling strategy.Nature communications · 2026Article
- Photoinduced H-Bonding EDA complex-enabled skeletal editing of furans to pyridazines.Nature communications · 2026Article
- Strategic Applications of Single-Atom Skeletal Editing in Natural Product Synthesis.Journal of the American Chemical Society · 2026Review
- Bridged scaffold editing of carbocycles and heterocycles.Nature communications · 2026Article
- Article
- Skeletal editing of tetrahydrofurans to pyrrolidines through O-to-N single atom swap.Nature communications · 2026Article
- Direct conversion from alkenes to alkynes.Nature · 2026Article
- Deacylative Polyfluoroarylation via C-C Cleavage of Alkyl Ketones.Organic letters · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
In drug development, replacement of a skeletal carbon with a sulfur atom can result in analogs of bioactive compounds with improved properties. Currently, the sulfur analogs are almost exclusively prepared by de novo synthesis; the existing approach to swap carbon with sulfur is inefficient and involves stoichiometric mercury reagents. In this study, we report a two-step carbonyl-to-sulfur (CO-to-S) atom swap approach, enabled by a rationally designed
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.