Evidence map›Paper›PMID 40504905›Full record

ArticleScience (New York, N.Y.)2025

A metabolite-based resistance mechanism against malaria.

Ana Figueiredo, Sonia Trikha Rastogi, Susana Ramos, Fátima Nogueira, Katherine De Villiers, António G Gonçalves de Sousa, Lasse Votborg-Novél, Cäcilie von Wedel, Pinkus Tober-Lau, Elisa Jentho and 27 more

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Ferroptosis is a Physiologic Vulnerability of Iron-Recycling Macrophages.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Bilirubin: translational perspectives.Pediatric research · 2026
    Review
  4. Article
  5. ATG5 Plays a Role inTransboundary and emerging diseases · 2026
    Article
  6. Biliverdin reductase A is a major determinant of protective NRF2 signaling.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

37 authors.

Ana FigueiredoGulbenkian Institute for Molecular Medicine (GIMM), Avenida Professor Egas Moniz, Lisboa, Portugal.ORCID 0000-0001-9075-2238
Sonia Trikha Rastogi *Gulbenkian Institute for Molecular Medicine (GIMM), Avenida Professor Egas Moniz, Lisboa, Portugal.ORCID 0000-0002-2333-7170
Susana Ramos *Gulbenkian Institute for Molecular Medicine (GIMM), Avenida Professor Egas Moniz, Lisboa, Portugal.ORCID 0000-0001-6356-1065
Fátima Nogueira *Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, Rua da Junqueira 100, Lisboa, Portugal.ORCID 0000-0003-0313-0778
Katherine De VilliersDepartment of Chemistry and Polymer Science, Stellenbosch University, Stellenbosch, South Africa.ORCID 0000-0002-2932-395X
António G Gonçalves de SousaTurku Bioscience Centre, University of Turku and Åbo Akademi University, Tykistökatu 6, Turku, Finland.ORCID 0000-0003-4779-6459
Lasse Votborg-NovélMax Planck Institute for Infection Biology, Berlin, Germany.ORCID 0000-0003-0381-0669
Cäcilie von WedelDepartment of Infectious Diseases and Intensive Care Medicine, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0009-0002-3391-3191
Pinkus Tober-LauDepartment of Infectious Diseases and Intensive Care Medicine, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0002-9148-3663
Elisa JenthoGulbenkian Institute for Molecular Medicine (GIMM), Avenida Professor Egas Moniz, Lisboa, Portugal.ORCID 0000-0002-4790-7860
Sara PagnottaGulbenkian Institute for Molecular Medicine (GIMM), Avenida Professor Egas Moniz, Lisboa, Portugal.
Miguel MesquitaGulbenkian Institute for Molecular Medicine (GIMM), Avenida Professor Egas Moniz, Lisboa, Portugal.ORCID 0000-0001-5927-790X
Silvia CardosoGulbenkian Institute for Molecular Medicine (GIMM), Avenida Professor Egas Moniz, Lisboa, Portugal.ORCID 0000-0003-4639-698X
Giulia BortolussiInternational Centre for Genetic Engineering and Biotechnology Padriciano, Trieste, Italy.
Andrés F MuroInternational Centre for Genetic Engineering and Biotechnology Padriciano, Trieste, Italy.ORCID 0000-0002-9628-0494
Erin M TranfieldGulbenkian Institute for Molecular Medicine (GIMM), Avenida Professor Egas Moniz, Lisboa, Portugal.ORCID 0000-0002-1542-7459
Jessica ThibaudDepartment of Chemistry and Polymer Science, Stellenbosch University, Stellenbosch, South Africa.ORCID 0000-0001-5917-3852
Denise DuarteGlobal Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, Rua da Junqueira 100, Lisboa, Portugal.ORCID 0000-0002-6853-7598
Ana Laura SousaGulbenkian Institute for Molecular Medicine (GIMM), Avenida Professor Egas Moniz, Lisboa, Portugal.ORCID 0000-0001-6067-8794
Sandra N PintoiBB-Institute for Bioengineering and Biosciences and i4HB-Institute for Health and Bioeconomy, Instituto Superior Técnico, Av. Rovisco Pais, Lisboa, Portugal.ORCID 0000-0002-3205-9459
Jamil KitokoGulbenkian Institute for Molecular Medicine (GIMM), Avenida Professor Egas Moniz, Lisboa, Portugal.ORCID 0000-0003-0973-5460
Ghyslain Mombo-NgomaCentre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.ORCID 0000-0003-2658-8706
Johannes MischlingerCentre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.
Sini JunttilaTurku Bioscience Centre, University of Turku and Åbo Akademi University, Tykistökatu 6, Turku, Finland.ORCID 0000-0003-3754-5584
Marta AlenquerCatólica Biomedical Research Centre (CBR), Católica Medical School - Universidade Católica Portuguesa, Palma de Cima, Lisboa, Portugal.ORCID 0000-0003-3062-1222
Maria João AmorimCatólica Biomedical Research Centre (CBR), Católica Medical School - Universidade Católica Portuguesa, Palma de Cima, Lisboa, Portugal.ORCID 0000-0002-4129-6659
Chirag VasavdaThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-4558-4698
Piter J BosmaAmsterdam UMC, University of Amsterdam, Tytgat Institute for Liver and Intestinal Research, AG&M, Meibergdreef 69-71, Amsterdam, Netherlands.ORCID 0000-0001-8302-1672
Sara ViolanteGulbenkian Institute for Molecular Medicine (GIMM), Avenida Professor Egas Moniz, Lisboa, Portugal.
Bernhard DrotleffMetabolomics Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID 0000-0003-0914-6578
Tiago PaixãoGulbenkian Institute for Molecular Medicine (GIMM), Avenida Professor Egas Moniz, Lisboa, Portugal.ORCID 0000-0003-2361-3953
Silvia PortugalMax Planck Institute for Infection Biology, Berlin, Germany.
Florian KurthDepartment of Infectious Diseases and Intensive Care Medicine, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0002-3807-473X
Laura L EloTurku Bioscience Centre, University of Turku and Åbo Akademi University, Tykistökatu 6, Turku, Finland.ORCID 0000-0001-5648-4532
Bindu D PaulThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-1862-6103
Rui MartinsGulbenkian Institute for Molecular Medicine (GIMM), Avenida Professor Egas Moniz, Lisboa, Portugal.ORCID 0000-0001-8106-6324
Miguel P SoaresGulbenkian Institute for Molecular Medicine (GIMM), Avenida Professor Egas Moniz, Lisboa, Portugal.ORCID 0000-0002-9314-4833

Funding

Neuroprotective actions of cystathionine g-lyase through gasotransmitter hydrogen sulfide signalingR01AG071512 · NIA · JOHNS HOPKINS UNIVERSITY · PI Bindu Paul · 2022 to 2026
$3.4M
Role of sulfhydration on the functions of the microtubule associated protein, TauR21AG073684 · NIA · JOHNS HOPKINS UNIVERSITY · PI PAUL, BINDU · 2021 to 2022
$450k
NIA NIH HHS R01 AG071512NIA NIH HHS R21 AG073684
6 · The paper itself

Abstract

Jaundice is a common presentation of

Indexed as

BilirubinDisease ResistanceGlucuronosyltransferaseJaundiceMalaria, FalciparumPlasmodium falciparumAnimalsErythrocytesFemaleHemeproteinsHumansLiverMaleMiceMitochondriaOxidoreductases Acting on CH-CH Group DonorsBilirubinGlucuronosyltransferaseHemeproteinshemozoinOxidoreductases Acting on CH-CH Group DonorspyrimidinePyrimidinesUGT1A1 Enzyme

Identifiers

PMID40504905
PMCPMC13019083

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.