ArticlePloS one2025
Cohort profile: The Belgian I AM frontier prospective cohort study for comprehensive health outcome exploration.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Reference intervals reimagined with IRIS for earlier detection and better disease monitoring.Scientific reports · 2026Article
- From ageing clocks to human digital twins in personalising healthcare through biological age analysis.NPJ digital medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe I AM Frontier cohort was set up to support proof-of-concepts aimed at personalized prevention and health promotion. The study was designed to identify patterns, markers and processes involved in the spectrum between health and early disease onset, with the aim of generating actionable insights in a clinical setting. STUDY
designA prospective cohort study. The study was approved by the ethics committee of the Antwerp University Hospital (RegN°: B300201938600).
methodsData collection in the I AM Frontier study spanned 12 months as a longitudinal small-scale cohort study (n = 30) conducted in the Antwerp region of Flanders, Belgium. Participants were employees of the company hosting the study, who did not have a clinical diagnosis and were between 45-60 years old.
resultsEven though no severe health problems were recorded at baseline, participants reported several physical complaints. There was a clear difference in longitudinal variation between clinical and research grade omics types, which might have affected their respective ability to detect intermediate molecular changes that were be linked to phenotype changes.
conclusionBy integrating findings from the IAF cohort into a large-scale cohort on personalized prevention, and incorporating new technologies for microsample data collection and participant engagement, we can develop more precise and individualized health recommendations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.