ArticleSmall (Weinheim an der Bergstrasse, Germany)2025
Polyethylene Glycol Nanofiller for Robust Lyophilization of Graphically Encoded Hydrogel Microparticles.
Article in Small (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Linkage Engineering in Porous Aromatic Frameworks for Recyclable Iodine Adsorption and Applications in Iodine-Mediated Organic Reactions.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Melt Electrowritten Scaffold-Reinforced Affibody-Conjugated Hydrogels for Controlled Bone Morphogenetic Protein-2 Delivery.bioRxiv : the preprint server for biology · 2025Article
- Polyethylene Glycol Nanofiller for Robust Lyophilization of Graphically Encoded Hydrogel Microparticles.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Graphically encoded hydrogel microparticle-based biosensing is a promising suspension microarray platform by virtue of multiplexing capability, robust sensitivity, and facilitated downstream analysis. However, the absence of a long-term and stable storage protocol for the hydrogel microparticle has been a bottleneck for the sensing platform to be adapted to practical fields. In this study, the polyethylene glycol (PEG) nanofiller-mediated lyophilization strategy of the hydrogel microparticles is presented. To inhibit the lyophilization-induced deformation of the porous structure and geometries of the particles, PEG is utilized as the filler material occupying the porous region in the hydrogel particles to prevent the interaction between polymer chains and the collapse of the porous structure. Based on the filler effect, the high decoding accuracy (more than 95%) for the lyophilized microparticles after reconstitution can be achieved by outstanding preservation of the particle geometries. Furthermore, the immunoassay performance of the antibody-functionalized microparticles lyophilized with PEG nanofiller is comparable to that of the non-lyophilized particles. Finally, the possibility of long-term storage (more than 6 months) of the lyophilized microparticles is confirmed by thermal aging. This finding is expected to promote the hydrogel microparticle-based sensing platform to be extended to practical fields via the innovation of the storage protocol.
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Registered trials
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