Evidence map›Paper›PMID 40504683›Full record

ArticleACS biomaterials science & engineering2025

Damage Associated Molecular Patterns (DAMPs) Mediate the Foreign Body Response to Poly(ethylene glycol) Diacrylate Hydrogels via Toll like Receptors.

Brittany J Thompson, Leila S Saleh, Emma L Carillion, Scott Alper, Stephanie J Bryant

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS biomaterials science & engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Brittany J ThompsonMaterials Science and Engineering Program, University of Colorado Boulder, Boulder, Colorado 80309, United States.
Leila S SalehChemical and Biological Engineering Department, University of Colorado Boulder, Boulder, Colorado 80309, United States.
Emma L CarillionChemical and Biological Engineering Department, University of Colorado Boulder, Boulder, Colorado 80309, United States.
Scott AlperDepartment of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado 80206, United States.
Stephanie J BryantMaterials Science and Engineering Program, University of Colorado Boulder, Boulder, Colorado 80309, United States.ORCID 0000-0003-1907-5216

Funding

Tunable Surface Coatings to Control Protein Dynamics and Attenuate the FBRR01AI177678 · NIAID · UNIVERSITY OF COLORADO · PI Stephanie J Bryant, Joel Kaar · 2024 to 2026
$2.1M
The Role of C-Flip in Mediating Pro-Survival Macrophages in the Foreign Body ResponseR21EB029261 · NIBIB · UNIVERSITY OF COLORADO · PI BRYANT, STEPHANIE J, JANSSEN, WILLIAM · 2020 to 2021
$447k
Prostaglandin E2 receptor 2 (EP2) as a Target for Prevention of the Foreign Body ResponseR21AR077419 · NIAMS · UNIVERSITY OF COLORADO · PI BRYANT, STEPHANIE J · 2020 to 2021
$367k
Mapping protein dynamics and their origin at biomaterial surfaces in vivoR21AR079154 · NIAMS · UNIVERSITY OF COLORADO · PI BRYANT, STEPHANIE J, CALVE, SARAH · 2021 to 2022
$367k
NIAID NIH HHS R01 AI177678NIAMS NIH HHS R21 AR077419NIAMS NIH HHS R21 AR079154NIBIB NIH HHS R21 EB029261
6 · The paper itself

Abstract

Poly(ethylene glycol) hydrogels prepared from PEG diacrylate (PEGDA) monomers are widely investigated for biological applications including drug delivery and tissue engineering. Despite their high-water contents, PEGDA hydrogels when implanted into the body induce a foreign body response (FBR). The overall goal of this study was to investigate the role of surface adsorbed proteins in the FBR to PEGDA hydrogels and determine whether they act as damage associated molecular patterns (DAMPs) to initiate inflammation. Toll-like receptors (TLRs) 2 and 4 are one of the primary receptors that recognize DAMPs. In vitro and in vivo studies were performed using wildtype (Wt), TLR2

Indexed as

AlarminsForeign-Body ReactionHydrogelsPolyethylene GlycolsToll-Like Receptor 2Toll-Like Receptor 4AnimalsMacrophagesMiceMice, Inbred C57BLMice, KnockoutNeutrophilsAlarminsHydrogelspoly(ethylene glycol)diacrylatePolyethylene GlycolsTlr2 protein, mouseTlr4 protein, mouseToll-Like Receptor 2Toll-Like Receptor 4DAMPsFBRmacrophagesneutrophilsPEGtoll-like receptors

Identifiers

PMID40504683
PMCPMC12752775

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.