Evidence map›Paper›PMID 40504482›Full record

ArticleMolecular neurobiology2025

Amelioration of Chemotherapy Induced Neuropathic Pain using Novel Nicotinic Acid Derivatives with possible HCN channel binding ability.

Akash Saini, Shiwani Sharma, Priyanka Rana, Bhawna Khanna, Tanzeer Kaur, Neelima Dhingra

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Akash SainiUniversity Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, 160014, India.
Shiwani SharmaDepartment of Biophysics, Panjab University, Chandigarh, 160014, India.
Priyanka RanaUniversity Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, 160014, India.
Bhawna KhannaUniversity Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, 160014, India.
Tanzeer KaurDepartment of Biophysics, Panjab University, Chandigarh, 160014, India. tanzeer.kaur@pu.ac.in.
Neelima DhingraUniversity Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, 160014, India. neelimad08@pu.ac.in.

Funding

Indian Council of Medical Research 5/4-5/188/Neuro/2019-NCD-1
6 · The paper itself

Abstract

One of the major debilitating side effects of cancer chemotherapy is neuropathic pain, which results from abnormal neural signaling and significantly diminishes patients' quality of life. Paclitaxel (PT), a widely used chemotherapeutic agent, induces peripheral nerve degeneration, leading to the development of painful neuropathy. In this study, PT was used to establish a mouse model of chemotherapy-induced peripheral neuropathy. Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels play a key role in regulating neuronal pacemaker activity. The HCN current (I

Indexed as

Antineoplastic AgentsHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsNeuralgiaAnimalsCell Line, TumorCell SurvivalGanglia, SpinalHumansHyperalgesiaMaleMiceMice, Inbred C57BLMolecular Docking SimulationPaclitaxelPotassium ChannelsProtein BindingAntineoplastic AgentsHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsPaclitaxelPotassium ChannelsChemotherapyHyperalgesiaHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsNeoplasmsNeuropathic painPaclitaxel

Identifiers

PMID40504482

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.