Evidence map›Paper›PMID 40504353›Full record

ArticleGeroScience2026

Impact of lifestyle factors on quantitative motor and cognitive performance: insights from a longitudinal study on healthy ageing.

Milan Zimmermann, Ulrike Sünkel, Isabel Wurster, Stefanie Lerche, Markus A Hobert, Claudia Schulte, Anna-Katharina von Thaler, Daniela Berg, Walter Maetzler, Andreas Fallgatter and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Milan ZimmermannCenter of Neurology, Department of Neurodegeneration and Hertie-Institute for Clinical Brain Research, University of Tuebingen, Hoppe Seyler-Strasse 3, 72076, City of Tuebingen, Germany. milan.zimmermann@t-online.de.ORCID 0000-0001-7066-7749
Ulrike SünkelGerman Center for Mental Health (DZPG), partner site Tuebingen, University Hospital of Psychiatry and Psychotherapy, University of Tuebingen, City of Tuebingen, Germany.
Isabel WursterCenter of Neurology, Department of Neurodegeneration and Hertie-Institute for Clinical Brain Research, University of Tuebingen, Hoppe Seyler-Strasse 3, 72076, City of Tuebingen, Germany.
Stefanie LercheCenter of Neurology, Department of Neurodegeneration and Hertie-Institute for Clinical Brain Research, University of Tuebingen, Hoppe Seyler-Strasse 3, 72076, City of Tuebingen, Germany.
Markus A HobertDepartment of Neurology, University Hospital Schleswig-Holstein and Kiel University, City of Kiel, Germany.
Claudia SchulteCenter of Neurology, Department of Neurodegeneration and Hertie-Institute for Clinical Brain Research, University of Tuebingen, Hoppe Seyler-Strasse 3, 72076, City of Tuebingen, Germany.
Anna-Katharina von ThalerDepartment of Neurology, University Hospital Schleswig-Holstein and Kiel University, City of Kiel, Germany.
Daniela BergDepartment of Neurology, University Hospital Schleswig-Holstein and Kiel University, City of Kiel, Germany.
Walter MaetzlerDepartment of Neurology, University Hospital Schleswig-Holstein and Kiel University, City of Kiel, Germany.
Andreas FallgatterGerman Center for Neurodegenerative Diseases (DZNE), University of Tuebingen, City of Tuebingen, Germany.
Gerhard W EschweilerGerman Center for Mental Health (DZPG), partner site Tuebingen, University Hospital of Psychiatry and Psychotherapy, University of Tuebingen, City of Tuebingen, Germany.
Thomas GasserCenter of Neurology, Department of Neurodegeneration and Hertie-Institute for Clinical Brain Research, University of Tuebingen, Hoppe Seyler-Strasse 3, 72076, City of Tuebingen, Germany.
Kathrin BrockmannCenter of Neurology, Department of Neurodegeneration and Hertie-Institute for Clinical Brain Research, University of Tuebingen, Hoppe Seyler-Strasse 3, 72076, City of Tuebingen, Germany.
Benjamin RoebenCenter of Neurology, Department of Neurodegeneration and Hertie-Institute for Clinical Brain Research, University of Tuebingen, Hoppe Seyler-Strasse 3, 72076, City of Tuebingen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The process of ageing is extremely variable in progression and phenotypic features including significant variations in disease milestones, such as cognitive impairment, frailty, or recurrent falls. Our aim was to analyze the influence of lifestyle factors on motor and cognitive performance in a longitudinal ageing study in older people on healthy ageing. We conducted a longitudinal analysis in a cohort of 744 older participants (mean 70 years) over an 8-year period. Cognitive performance was assessed using the Consortium to Establish a Registry for Alzheimer's Disease (CERADplus) test battery, including the Trail Making Test (TMT) for executive function. Gait performance was evaluated by measuring gait velocity. Dual-task performance was assessed by measuring gait velocity while checking boxes. Body Mass Index (BMI) was also recorded. Symptoms of depression were examined using Beck's Depression Inventory (BDI-II). We observed higher cognitive functions in individuals adhering to a high-frequency physical activity regimen and a resilient plant-based diet. Additionally, these individuals exhibited lower BDI-II scores and experienced mitigated cognitive decline. Participants who combined high physical activity, a high intake of plant-based foods, and extensive education-referred to as having a high "successful ageing index" -maintained nearly constant CERADplus total scores over the 8-year period. Protective lifestyle factors are linked to better cognitive and motor performance and a slower decline in cognitive function, indicating healthy ageing. Since the factors diet and exercise are modifiable, adopting them may enhance cognitive performance and autonomy in older adults.

Indexed as

CognitionHealthy AgingLife StyleAgedAged, 80 and overCognitive DysfunctionDepressionExecutive FunctionExerciseFemaleGaitHumansLongitudinal StudiesMaleHealthy lifestyleLongitudinal ageing studyNutritionProtective score

Identifiers

PMID40504353
PMCPMC12972355

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.