Evidence map›Paper›PMID 40504299›Full record

ArticleNeurochemical research2025

Selective Vulnerability of Hippocampi for Nitric Oxide Synthases in Alzheimer's Disease Pathology and Cognitive Abilities.

Alberto Fernando Oliveira Justo, Eliana Cristina de Brito Toscano, Natalia Gomes Goncalves, Renata Elaine Paraízo Leite, Vitor Ribeiro Paes, Ricardo Nitrini, Carlos Pasqualucci, Chin Jia Lin, Lea T Grinberg, Claudia Kimie Suemoto

Abstract read
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In one paragraph

Article in Neurochemical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alberto Fernando Oliveira JustoDivision of Geriatrics, Department of Internal Medicine, University of São Paulo Medical School, São Paulo, Brazil. albertofojusto@gmail.com.ORCID http://orcid.org/0000-0001-5531-0485
Eliana Cristina de Brito ToscanoDepartment of Pathology, Federal University of Juiz de Fora Medical School, Juiz de Fora, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-8756-0689
Natalia Gomes GoncalvesDivision of Geriatrics, Department of Internal Medicine, University of São Paulo Medical School, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-5253-5483
Renata Elaine Paraízo LeitePhysiopathology in Laboratory (LIM-22), Department of Pathology, University of São Paulo Medical School, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-5878-398X
Vitor Ribeiro PaesPhysiopathology in Laboratory (LIM-22), Department of Pathology, University of São Paulo Medical School, São Paulo, Brazil.
Ricardo NitriniDepartment of Neurology, University of São Paulo Medical School, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-5721-1525
Carlos PasqualucciPhysiopathology in Laboratory (LIM-22), Department of Pathology, University of São Paulo Medical School, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-6608-2473
Chin Jia LinLaboratory of Molecular Pathology (LIM-22), Department of Pathology, University of São Paulo Medical School, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-7489-560X
Lea T GrinbergMemory and Aging Center, University of California San Francisco, San Francisco, USA.ORCID http://orcid.org/0000-0002-6809-0618
Claudia Kimie SuemotoDivision of Geriatrics, Department of Internal Medicine, University of São Paulo Medical School, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-5942-4778

Funding

Alzheimer's Association 24CBIDR-1185483Fundação de Amparo à Pesquisa do Estado de São Paulo 21/14171-8
6 · The paper itself

Abstract

Alzheimer's disease (AD) neuropathological changes (ADNC) are characterized by amyloid plaques and neurofibrillary tangles. The role of nitric oxide synthase (NOS) in disease progression remains unclear. This study investigates the expression of neural, inducible, and endothelial NOS (nNOS, iNOS, eNOS) and 3-nitrotyrosine (3-NT) in the hippocampal subregions of individuals with ADNC and their association with cognitive abilities. Immunohistochemistry was performed on hippocampal samples from 10 individuals with ADNC and 10 age- and sex-matched controls to detect NOS enzymes, and 3-NT expression in CA1, CA2, CA3, and CA4. Logistic ordinal regressions evaluated associations of NOS and 3-NT expression with AD pathology, while linear regressions assessed relationships with cognitive abilities. Overexpression of nNOS was observed in all hippocampal subregions in ADNC participants. iNOS expression was elevated in CA1 and CA3, while eNOS showed increased levels only in CA3. 3-NT was significantly higher in CA3 of ADNC participants. nNOS expression in all hippocampal regions correlated with AD pathology and cognitive impairment. iNOS in CA3 was associated with AD pathology and cognitive scores. No associations were found for eNOS, and 3-NT in CA3 correlated with cognitive impairment. Associations of nNOS and iNOS with neuropathology and cognition suggest a role for NOS in AD pathophysiology.

Indexed as

Alzheimer DiseaseCognitionHippocampusNitric Oxide SynthaseAgedAged, 80 and overFemaleHumansMaleNitric Oxide Synthase Type INitric Oxide Synthase Type IINitric Oxide Synthase Type IIITyrosine3-nitrotyrosineNitric Oxide SynthaseNitric Oxide Synthase Type INitric Oxide Synthase Type IINitric Oxide Synthase Type IIITyrosine3-nitrotyrosine (3-NT)Alzheimer's diseaseCognitionHippocampal subregionsNeuritic plaquesNeurofibrillary tanglesNeuroinflammationNitric oxide synthaseNOSOxidative stress

Identifiers

PMID40504299

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.