Evidence map›Paper›PMID 40504297›Full record

ArticleNeurochemical research2025

Histone Acetylation Modifications and HDACs are Associated with Resilience or Susceptibility to Stress in a Rat Model of Major Depressive Disorder.

Lucas Santos, Luana Possa, Nicole Fröhlich, Luiza Behrens, Camila Barbosa, Camila Tiefensee-Ribeiro, Daniel Pens Gelain, Roberto F Almeida, José Cláudio Fonseca Moreira

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Article in Neurochemical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lucas SantosCentro de Estudos em Estresse Oxidativo, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. lucassantos_17@hotmail.com.ORCID http://orcid.org/0000-0001-8296-0248
Luana PossaCentro de Estudos em Estresse Oxidativo, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Nicole FröhlichCentro de Estudos em Estresse Oxidativo, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Luiza BehrensCentro de Estudos em Estresse Oxidativo, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Camila BarbosaCentro de Estudos em Estresse Oxidativo, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Camila Tiefensee-RibeiroCentro de Estudos em Estresse Oxidativo, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Daniel Pens GelainCentro de Estudos em Estresse Oxidativo, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Roberto F AlmeidaCentro de Ciências Químicas Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Pelotas, Brazil.
José Cláudio Fonseca MoreiraCentro de Estudos em Estresse Oxidativo, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Major Depressive Disorder (MDD) is a multifactorial psychiatric condition. Evidence shows that stress plays a fundamental role in the pathophysiology of MDD. Studies have hypothesized that some changes in histone acetylation patterns and histone deacetylase (HDACs) are closely associated with the development of MDD. Histone acetylation and deacetylation are covalent modifications that influence chromatin structure, serving as key mechanisms for controlling gene expression. The aim of this study was to investigate the involvement of H2AK5ac, H2BK5ac, H3K9ac, and H4K8ac, as well as HDACs, HDAC1-7 in rats subjected to the chronic unpredictable moderate stress (CUMS) model. For this, 29 male Wistar rats were exposed to the CUMS protocol or designated as a control group. After behavioral tests the animals were classified as resilient or susceptible to the depressive-like phenotype. Subsequently, the acetylation patterns of histones and HDACs were evaluated in the hypothalamus, hippocampus, and parietal cortex. Observing sucrose consumption, open field behavior, and object recognition, it is possible to identify characteristic phenotypes of animals that are either susceptible to the depressive-like phenotype or resilient to the CUMS protocol. For the first time, it was demonstrated that the H3K9ac, H4K8ac, HDAC2, HDAC3, HDAC4, and HDAC5 patterns are associated with resilience or susceptibility to the depressive-like phenotype in a brain region-specific manner. Results from this study provide evidence that H3 and H4 acetylation's and HDACs are connected with the development of the resilient or susceptible depressive-like phenotype, hence contributing to new advances in understanding the pathophysiology of MDD and discovering mechanisms behind resilience.

Indexed as

Histone DeacetylasesHistonesMajor Depressive DisorderResilience, PsychologicalStress, PsychologicalAcetylationAnimalsDisease Models, AnimalDisease SusceptibilityMaleRatsRats, WistarHistone DeacetylasesHistonesCUMSEpigeneticsHistone acetylationHistone deacetylasesMajor depressive disorderResilience

Identifiers

PMID40504297

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.