Evidence map›Paper›PMID 40504153›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

LDL receptor-mediated endocytosis of

Hunter W Kuhn, Madeleine R Smither, Rachel J Jin, Christina A Collins, Hongming Ma, Jason Sina, Joseph P Gaut, Michael S Diamond, David A Hunstad

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. LDL receptor promotes urinary tract infection by α-hemolysin-producingProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Reply to Possenriede et al.: LDLR as a targetable HlyA receptor inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hunter W KuhnDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-7876-3521
Madeleine R SmitherDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0009-0005-6922-842X
Rachel J JinDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110.
Christina A CollinsDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110.
Hongming MaDepartment of Medicine, Washington University School of Medicine, St. Louis, MO 63110.
Jason SinaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.
Joseph P GautDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.
Michael S DiamondDepartment of Medicine, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-8791-3165
David A HunstadDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-9848-0975

Funding

TRAINING PROGRAM IN CELLULAR AND MOLECULAR BIOLOGYT32GM007067 · NIGMS · WASHINGTON UNIVERSITY · PI TRUE-KROB, HEATHER L · 1985 to 2020
$20.4M
Cellular and Molecular Basis of Sex Specificity in UTI PathogenesisR01DK126697 · NIDDK · WASHINGTON UNIVERSITY · PI EARL, ASHLEE MIRIAM, HUNSTAD, DAVID · 2020 to 2024
$2.5M
Novel Type 1 Pilus Receptors in Pyelonephritis and Recurrent UTIR01AI158418 · NIAID · WASHINGTON UNIVERSITY · PI HUNSTAD, DAVID · 2021 to 2025
$2.0M
Androgen Enhancement of E. coli Hemolysin Toxicity during Pyelonephritis.F31AI176711 · NIAID · WASHINGTON UNIVERSITY · PI KUHN, HUNTER W · 2024 to 2024
$35k
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) F31-AI176711HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01-AI158418HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01-DK126697HHS | NIH | National Institute of General Medical Sciences (NIGMS) T32-GM007067NIAID NIH HHS F31 AI176711NIAID NIH HHS R01 AI158418NIDDK NIH HHS R01 DK126697NIGMS NIH HHS T32 GM007067
6 · The paper itself

Abstract

The α-hemolysin (HlyA) of uropathogenic

Indexed as

EndocytosisEpithelial CellsEscherichia coli ProteinsHemolysin ProteinsReceptors, LDLUropathogenic Escherichia coliAnimalsEscherichia coli InfectionsHumansKidneyMicePyelonephritisEscherichia coli ProteinsHemolysin ProteinsHlya protein, E coliReceptors, LDLhemolysinLDLRRTX toxin

Identifiers

PMID40504153
PMCPMC12184420

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.