Evidence map›Paper›PMID 40504145›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Unraveling the role of rat and flea population dynamics on the seasonality of plague epidemics in Madagascar.

Fanohinjanaharinirina Rasoamalala, Beza Ramasindrazana, Mamionah J Parany, Soloandry Rahajandraibe, Lovasoa Randriantseheno, Soanandrasana Rahelinirina, Olivier Gorgé, Eric Valade, Mireille Harimalala, Minoarisoa Rajerison and 2 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Fanohinjanaharinirina RasoamalalaPlague Unit, Institut Pasteur de Madagascar, Antananarivo 101, Madagascar.ORCID 0000-0001-7841-7963
Beza RamasindrazanaPlague Unit, Institut Pasteur de Madagascar, Antananarivo 101, Madagascar.
Mamionah J ParanyPlague Unit, Institut Pasteur de Madagascar, Antananarivo 101, Madagascar.
Soloandry RahajandraibeDepartment for the Control of Transmissible Diseases, Central Laboratory for Plague, Ministry of Public Health, Antananarivo 101, Madagascar.ORCID 0009-0007-3631-3964
Lovasoa RandriantsehenoPlague Unit, Institut Pasteur de Madagascar, Antananarivo 101, Madagascar.ORCID 0000-0003-4776-2662
Soanandrasana RahelinirinaPlague Unit, Institut Pasteur de Madagascar, Antananarivo 101, Madagascar.
Olivier GorgéInstitut de Recherche Biomédicale des Armées, Brétigny-sur-Orge 91220, France.ORCID 0000-0002-6096-080X
Eric ValadeInstitut de Recherche Biomédicale des Armées, Brétigny-sur-Orge 91220, France.
Mireille HarimalalaMedical Entomology Unit, Institut Pasteur de Madagascar, Antananarivo 101, Madagascar.
Minoarisoa RajerisonPlague Unit, Institut Pasteur de Madagascar, Antananarivo 101, Madagascar.
Simon Cauchemez *Mathematical Modelling of Infectious Diseases Unit, Global Health Department, Institut Pasteur, Université Paris Cité, INSERM U1332, CNRS UMR2000, Paris 75015, France.ORCID 0000-0001-9186-4549
Antoine Brault *Mathematical Modelling of Infectious Diseases Unit, Global Health Department, Institut Pasteur, Université Paris Cité, INSERM U1332, CNRS UMR2000, Paris 75015, France.

Funding

INCEPTION PIA/ANR-16-CONV-0005Laboratoire d'Excellence Integrative Biology of Emerging Infectious Diseases Grant ANR-10-LABX-62-IBEID
6 · The paper itself

Abstract

Plague continues to pose a public health problem in multiple regions of the world, including Madagascar, where it is characterized by a pronounced seasonal pattern. The drivers of plague seasonality remain poorly understood. Using a deterministic compartmental model, calibrated to rat and flea capture data, serological data collected in active rural foci, and human plague surveillance data, we analyzed the effects of seasonal rat and flea population dynamics on plague transmission. The models that incorporated seasonal fluctuations in rat and flea populations provided better predictive performances than those that did not. We found that a simpler mass-action model also performed well. Driven by these seasonal changes, the effective reproduction number (R

Indexed as

EpidemicsPlagueSeasonsSiphonapteraAnimalsHumansMadagascarModels, BiologicalPopulation DynamicsRatsMadagascarmodelingplaguepublic healthseasonality

Identifiers

PMID40504145
PMCPMC12184415

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.