ArticleRheumatology (Oxford, England)2025
Comparison of quantitative lung ultrasound scores with automated quantitative CT: to overcome the ultrasound limitations.
Article in Rheumatology (Oxford, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Computational interpretation of modified lung ultrasound performance in CTD-ILD.Clinical rheumatology · 2026Article
- International evidence-based recommendations for point-of-care lung ultrasound : 2025 focused update of the 2012 recommendations.Intensive care medicine · 2026Article
- Diagnostic performance of lung ultrasound for systemic sclerosis-associated interstitial lung disease: an international cross-sectional study from two tertiary care centers.Clinical rheumatology · 2026Article
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Authors and funding
14 authors.
Funding
Abstract
objectivesLung ultrasound (LUS) is emerging as a valuable tool for assessing systemic sclerosis-associated interstitial lung disease (SSc-ILD), although it traditionally explores only superficial lung regions. Building upon our preliminary findings, this study investigated correlations between quantitative LUS scores and automated quantitative computed tomography (qCT) measurement of ILD extent, including both superficial and deeper lung involvement.
methodsBetween 2021 and 2023, 82 consecutive SSc patients underwent concurrent LUS and CT scans. Total B-lines (BL) count (range 0-140) and our novel pleural line irregularity (PLI) score (range 0-28) were obtained using a 14-intercostal space scanning protocol. CT scans were analysed by automated texture analysis software, quantifying volumes of ILD, ground-glass opacities (GGO) and reticulations (RET), segmented in three levels (apices, midfields, bases) and subdivided in surface and core lung parenchyma.
resultsTotal BL count and PLI score correlated with total ILD, GGO and RET volumes (all P < 0.0001), as well as with surface and core ILD volumes (all P < 0.0001). Basal lung BLs and PLI score correlated with basal ILD, GGO, RET (all P < 0.005) and corresponding surface and core ILD volumes (all P < 0.005). Mid-lung PLI correlated also with corresponding ILD-related changes and surface and core ILD (all P < 0.005). These associations were confirmed by multivariate regression analysis.
conclusionsQuantitative LUS score correlated with qCT-defined ILD extent, especially at lung bases. LUS scores (particularly the novel PLI score) were found to correlate with deeper ILD volume, suggesting potential to overcome traditional LUS limitations related to superficial lung assessment.
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