Evidence map›Paper›PMID 40503958›Full record

ArticleAntimicrobial agents and chemotherapy2025

Structure and mechanism of taniborbactam inhibition of the cefepime-hydrolyzing, partial R2-loop deletion

Andrew R Mack, Vijay Kumar, Christopher R Bethel, Magdalena A Taracila, Brittany A Miller, Tsuyoshi Uehara, David A Six, Krisztina M Papp-Wallace, Focco van den Akker, Robert A Bonomo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andrew R Mack *Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA.ORCID 0000-0002-0131-7996
Vijay Kumar *Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA.
Christopher R BethelResearch Service, VA Northeast Healthcare System, Cleveland, Ohio, USA.
Magdalena A TaracilaResearch Service, VA Northeast Healthcare System, Cleveland, Ohio, USA.
Brittany A MillerVenatorx Pharmaceuticals Inc., Malvern, Pennsylvania, USA.
Tsuyoshi UeharaVenatorx Pharmaceuticals Inc., Malvern, Pennsylvania, USA.ORCID 0000-0001-6994-4286
David A SixVenatorx Pharmaceuticals Inc., Malvern, Pennsylvania, USA.ORCID 0000-0002-9013-1711
Krisztina M Papp-WallaceResearch Service, VA Northeast Healthcare System, Cleveland, Ohio, USA.ORCID 0000-0002-9976-7898
Focco van den AkkerDepartment of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA.ORCID 0000-0001-9210-3565
Robert A BonomoDepartment of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA.ORCID 0000-0002-3299-894X

Funding

Understanding ceftazidime resistance in SHV B-LactamasesR01AI063517 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI BONOMO, ROBERT A. · 2005 to 2023
$4.9M
Biomedical Advanced Research and Development Authority HHSO100201900007CNational Institute of Allergy and Infectious Diseases R01AI063517NIAID NIH HHS R01 AI063517
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anti-Bacterial Agentsbeta-Lactamase InhibitorsBorinic AcidsCefepimeCephalosporinasePseudomonas aeruginosaAzabicyclo CompoundsBacterial Proteinsbeta-LactamasesCarboxylic AcidsCeftazidimeCephalosporinsDrug CombinationsHydrolysisMicrobial Sensitivity TestsTazobactamAnti-Bacterial AgentsAzabicyclo CompoundsBacterial Proteinsbeta-Lactamase Inhibitorsbeta-LactamasesBorinic AcidsCarboxylic AcidsCefepimeCeftazidimeCephalosporinaseCephalosporinsDrug CombinationstaniborbactamTazobactamantibiotic resistancebeta-lactamase inhibitorsbeta-lactamsPseudomonas aeruginosa

Identifiers

PMID40503958
PMCPMC12217481

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.