Evidence map›Paper›PMID 40503928›Full record

ArticleACS infectious diseases2025

Improved Radiosynthesis of [

Mona Sarhan, Anil M Shelke, Kishor Mane, Ravindra Jadhav, Byeonghoon Jeon, Oscar Nino-Meza, Xueyi Chen, Joel S Freundlich, Sanjay K Jain, Laurence Carroll

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mona SarhanCenter for Infection and Inflammation Imaging Research, Center for Tuberculosis Research, and Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States.
Anil M ShelkeDepartment of Pharmacology, Physiology, and Neuroscience, Rutgers University-New Jersey Medical School, Newark, New Jersey 07103, United States.
Kishor ManeDepartment of Pharmacology, Physiology, and Neuroscience, Rutgers University-New Jersey Medical School, Newark, New Jersey 07103, United States.
Ravindra JadhavDepartment of Pharmacology, Physiology, and Neuroscience, Rutgers University-New Jersey Medical School, Newark, New Jersey 07103, United States.
Byeonghoon JeonCenter for Infection and Inflammation Imaging Research, Center for Tuberculosis Research, and Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States.
Oscar Nino-MezaCenter for Infection and Inflammation Imaging Research, Center for Tuberculosis Research, and Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States.
Xueyi ChenCenter for Infection and Inflammation Imaging Research, Center for Tuberculosis Research, and Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States.ORCID 0000-0003-1574-7759
Joel S FreundlichDepartment of Pharmacology, Physiology, and Neuroscience, Rutgers University-New Jersey Medical School, Newark, New Jersey 07103, United States.
Sanjay K JainCenter for Infection and Inflammation Imaging Research, Center for Tuberculosis Research, and Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States.ORCID 0000-0001-9620-7070
Laurence CarrollRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States.ORCID 0000-0001-8164-9474

Funding

Preclinical modeling to study Tuberculous MeningitisR01AI145435 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2020 to 2024
$4.0M
Measuring Intralesional Drug Exposures in Cavitary TB using Noninvasive In Vivo PET ImagingR01AI153349 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2020 to 2024
$3.8M
Pro-apoptotic Drugs as Host-Directed Treatments for Pulmonary Tuberculosis”R01AI190038 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Sanjay K Jain · 2025 to 2026
$1.6M
Pro-apoptotic Drugs as Host-Directed Treatments for Pulmonary TuberculosisR56AI179012 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2024 to 2024
$818k
Metal Fluorination For biomolecules: Expanding The Radiofluorination ToolboxR21EB035675 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Laurence Carroll · 2025 to 2026
$349k
NIAID NIH HHS R01 AI145435NIAID NIH HHS R01 AI153349NIAID NIH HHS R01 AI190038NIAID NIH HHS R56 AI179012NIBIB NIH HHS R21 EB035675
6 · The paper itself

Abstract

The development of radiolabeled antibiotics for positron emission tomography/computed tomography (PET/CT) imaging has the potential to substantially improve our ability to measure compartment-specific antibiotic exposures for various infections. This study focuses on the radiosynthesis and optimization of fluorine-18 [

Indexed as

Anti-Bacterial AgentsFluorine RadioisotopesOxazolidinonesRadiopharmaceuticalsAnimalsFemaleLinezolidMiceMycobacterium tuberculosisPositron-Emission TomographyPositron Emission Tomography Computed TomographyTissue DistributionTuberculosisAnti-Bacterial AgentsFluorine-18Fluorine RadioisotopesLinezolidOxazolidinonesRadiopharmaceuticalsantibioticcopper-mediated radiofluorinationfluorine-18oxazolidinonetuberculosis

Identifiers

PMID40503928
PMCPMC12254010

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.