ReviewExpert opinion on drug delivery2025
Recent advances in extracellular matrix-inspired nanocarriers.
Review in Expert opinion on drug delivery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Collagenase-mediated extracellular matrix targeting for enhanced drug penetration and therapeutic efficacy in nanoscale delivery systems for cancer therapy.Journal of nanobiotechnology · 2025Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
introductionECM-inspired nanocarriers have emerged as a promising platform for drug delivery due to their unique advantages over traditional nanocarrier systems. The ECM is a complex three-dimensional network comprising proteins and polysaccharides that play a key role in maintaining tissue function and homeostasis. Recent advances in the design and synthesis of ECM-inspired nanocarriers have resulted in superior efficacy, targeting, and responsive delivery systems. AREAS COVERED: This review covers ECM-inspired nanocarriers, focusing on their design and fabrication methods, and applications in drug delivery, tissue engineering, and regenerative medicine. Specific focus is placed on nanocarriers derived from elastin, collagen, hyaluronic acid, and their combinations, creating 'conjugate nanoparticles' published in the last 5 years. This review also discusses the benefits of mimicking ECM structure and function, the advantages of each nanoparticle type, challenges associated with large-scale synthesis, and immunogenicity. EXPERT OPINION: ECM-inspired nanocarriers are a novel avenue for the delivery of therapeutics with recent emphasis placed on complex, responsive systems. While substantial progress has been made in the design and application of these nanocarriers in pre-clinical studies, significant challenges remain, particularly concerning immunogenicity, scalability, and the need for more robust clinical data, before these innovations can be widely translated into clinical practice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.