ArticleBioanalysis2025
Quantitation of TAK-981 in human plasma via LC-MS/MS and its application in clinical trials.
Article in Bioanalysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTAK-981 is a highly effective and selective inhibitor of the small ubiquitin-like modifier (SUMO) activating enzyme, and it promotes the expression of type I interferons (IFN-Is). Developing a sensitive bioanalytical assay for quantitating TAK-981 is essential in the clinical investigations for oncology drug development. MATERIALS &
methodsTAK-981 and its stable isotope labeled compound (TAK-981
resultsThis assay was successfully validated from 0.1 ng/mL to 100 ng/mL with good accuracy and precision and has been applied to support clinical studies.
conclusionA sensitive and robust LC-MS/MS assay was validated for TAK-981 in human plasma for the first time.
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