ArticleACR open rheumatology2025
Discriminating Disease Flare From Infection in Febrile Patients With Systemic Lupus Erythematosus in a Safety-Net Hospital System: A Multicenter Study.
Article in ACR open rheumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Development and temporal validation of a clinical prediction model to identify bacterial infection in hospitalised patients with systemic lupus erythematosus.Lupus science & medicine · 2026Article
- Association of Inflammation-Based Ratios with Endothelial Dysfunction Markers and Clinical Parameters in Limited Cutaneous Systemic Sclerosis.Journal of clinical medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectiveThe objective of this study was to assess clinical laboratory parameters that distinguish between disease flare and infection in febrile patients with systemic lupus erythematosus (SLE) at safety-net hospitals in Los Angeles.
methodsWe reviewed electronic medical records of patients admitted from August 1, 2016, through July 31, 2019, categorizing them as disease flare, bacterial infection (culture positive), culture-negative infection, and both flare and infection. Laboratory parameters collected within 48 hours of admission (complete blood cell count with differential, liver function panel, erythrocyte sedimentation rate [ESR], C-reactive protein [CRP], C3, C4, lactate, procalcitonin, and ferritin) were analyzed.
resultsSeveral laboratory parameters significantly distinguished febrile patients with disease flare from those with infection. An optimized multivariable logistic regression model revealed that an elevated ESR:CRP ratio (>1.17), low white blood cell (WBC) count (<6.25 × 10
conclusionThe ESR:CRP ratio plus C3 and C4 levels, WBC count, neutrophil count, and monocyte count discriminate flare from either culture-positive or culture-negative infection in febrile patients with SLE. Our findings warrant prospective validation.
Identifiers
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Registered trials
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