ArticleJournal of clinical laboratory analysis2025
Plasma Nerve Growth Factor Is Associated With Early Postoperative Shoulder Stiffness in Patients With Degenerative Rotator Cuff Tears.
Article in Journal of clinical laboratory analysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Plasma Nerve Growth Factor Is Associated With Early Postoperative Shoulder Stiffness in Patients With Degenerative Rotator Cuff Tears.Journal of clinical laboratory analysis · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
objectiveThis study was to investigate the correlation between plasma nerve growth factor (NGF) and postoperative range of motion (ROM) in patients with rotator cuff tears (RCT).
methodsFrom January 2022 to March 2024, a total of 135 patients with degenerative RCT were included. The patients were divided into Stiff group (n = 42) and Non-Stiff group (n = 93) accordingly. The receiver operating characteristic curve (ROC) and area under the curve (AUC) were drawn to evaluate the predictive value of plasma NGF for postoperative joint stiffness. The Spearman test was used to analyze the relationship between plasma NGF and joint motion, VAS score, and joint function scores (UCLA score and Constant score). The relationship between plasma NGF and postoperative ROM and risk of joint stiffness was evaluated by restricted cubic spline (RCS) analysis of independent variables.
resultsIn the preoperative and postoperative comparison, the two groups improved in joint flexion, VAS pain score, and joint function, except that the external rotation of the Stiff group did not change before and after surgery. After surgery, the ROM of the Stiff group was still significantly limited, and the ROM and joint function scores were lower than those of the Non-Stiff group (p < 0.01).
conclusionThis study suggests that reduced plasma NGF in patients with degenerative RCT may be associated with early shoulder stiffness, showing a negative non-linear dose-response relationship. On a clinical basis, plasma NGF is beneficial to quantify the risk of early shoulder stiffness after RCT.
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