Evidence map›Paper›PMID 40503527›Full record

ArticleCurrent research in food science2025

Stability of nutrients in complex liquid and powder food matrices: learnings from shelf-life studies in foods for special medical purposes.

Laurent Ameye, Sophie de Brouwer, Donald L Gilliland, Julia Heckmann, Kaushik Janakiraman, Bridget-Anne Kirwan, Xavier Lavigne, Francisco Moya, Vanessa Zammit

Abstract read
In one paragraph

Article in Current research in food science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Laurent AmeyeNestlé Health Science, Vevey, Switzerland.
Sophie de BrouwerSOCAR Research SA, Nyon, Switzerland.
Donald L GillilandAbbott Nutrition, Colombus, USA.
Julia HeckmannFresenius Kabi Deutschland GmbH, Bad Homburg, Germany.
Kaushik JanakiramanReckitt, Slough, UK.
Bridget-Anne KirwanSOCAR Research SA, Nyon, Switzerland.
Xavier LavigneAbbott Nutrition, Diegem, Belgium.
Francisco MoyaAbbott Nutrition, Granada, Spain.
Vanessa ZammitDanone Research and Innovation, Utrecht, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated the effects of physical state, temperature, pH, protective atmosphere, protein hydrolysis, fats, fibre, packaging and flavour on nutrient degradation by analyzing the results of shelf-life studies of 1400 recipes of Foods for Special Medical Purposes (FSMP). For each nutrient, the adaptive LASSO method was applied to identify which factors drive degradation. Degradation percentage was estimated by repeated measure model using the list of identified factors and time as covariates. Nutrients that had little or no degradation under all tested conditions included fat, protein, individual fatty acids, minerals and the vitamins B2, B6, E, K, niacin, biotin and beta carotene. Important nutrient degradation which was, mainly driven by temperature, were only observed in vitamin A (powder products), vitamin C, B1 and D (liquid products) and pantothenic acid (acidified liquids). These nutrients used as tracers in stability studies would be sufficient to confirm the nutritional suitability of products until their end of shelf-life. Our results show that the most important factors driving nutrient degradation were liquid format, temperature and pH. The fat content, relative humidity, presence of fibre, flavours or packaging size/type did not impact on the stability of any nutrients. These results provide a sound basis to guide health authorities to define which nutrients should ideally be included in FSMP shelf-life studies in addition to providing valuable insight into which factors impact on nutrient degradation in general.

Indexed as

DegradationNutrientShelf-lifeStability

Identifiers

PMID40503527
PMCPMC12158562

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.