Evidence map›Paper›PMID 40503513›Full record

ReviewEClinicalMedicine2025

The importance of long-term studies in children following viral infection of the central nervous system.

Ivanildo P Sousa, Patrícia C de Sequeira, Anne Caroline S B Marcos, Nathalia A A Almeida, Hanalise V Huff, Tom Solomon, Vanessa S de Paula

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in EClinicalMedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Neurodegenerative and Cognitive Consequences of Long COVID.International journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ivanildo P SousaLaboratory of Molecular Virology and Parasitology, Oswaldo Cruz Institute/Oswaldo Cruz Foundation, Av Brasil 4365, Manguinhos, Rio de Janeiro, 21045-360, Brazil.
Patrícia C de SequeiraLaboratory of Arboviruses and Hemorrhagic Viruses, Oswaldo Cruz Institute/Oswaldo Cruz Foundation, Av Brasil 4365, Manguinhos, Rio de Janeiro, 21045-360, Brazil.
Anne Caroline S B MarcosLaboratory of Arboviruses and Hemorrhagic Viruses, Oswaldo Cruz Institute/Oswaldo Cruz Foundation, Av Brasil 4365, Manguinhos, Rio de Janeiro, 21045-360, Brazil.
Nathalia A A AlmeidaLaboratory of Molecular Virology and Parasitology, Oswaldo Cruz Institute/Oswaldo Cruz Foundation, Av Brasil 4365, Manguinhos, Rio de Janeiro, 21045-360, Brazil.
Hanalise V HuffNational Institutes of Health, National Institute of Neurological Disorders and Stroke, Building 10, Center Drive, Bethesda, MD, 20892, USA.
Tom SolomonThe Pandemic Institute, Liverpool, L7 3FA, UK.
Vanessa S de PaulaLaboratory of Molecular Virology and Parasitology, Oswaldo Cruz Institute/Oswaldo Cruz Foundation, Av Brasil 4365, Manguinhos, Rio de Janeiro, 21045-360, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Viruses are a major cause of central nervous system (CNS) infections in pediatric patients, often resulting in significant rates of morbidity and mortality. Many viruses have been implicated in neurodevelopmental disorders with long-term consequences that significantly impact families, healthcare systems, economies, and society. Unfortunately, however, long-term follow-up studies evaluating neurodevelopmental outcomes in pediatric survivors of viruses affecting the nervous system are limited. The disease burden of CNS infection is often highest in regions where resources are lowest, such as in low- and middle-income countries (LMICs). In this viewpoint, we highlight the importance of longitudinal studies in tracking the impact of CNS viral infections over time with a goal of better understanding and evaluating the efficacy of various interventions and identifying opportunities for early intervention to mitigate long-term disability.

Indexed as

CNS infectionsEncephalitisMeningitisNeurodevelopmental disordersPost-infectious cognitive/psychiatric sequelaeViral neuroinfection

Identifiers

PMID40503513
PMCPMC12158479

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.