Evidence map›Paper›PMID 40503367›Full record

ReviewWorld journal of stem cells2025

Stem cell therapy for retinal pigment epithelium disorders.

Francesco Saverio Sorrentino, Francesco Parmeggiani, Lorenzo Gardini, Luigi Fontana, Mutali Musa, Caterina Gagliano, Marco Zeppieri

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of stem cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Francesco Saverio SorrentinoDepartment of Surgical Sciences, Unit of Ophthalmology, Ospedale Maggiore, Bologna 40100, Italy.
Francesco ParmeggianiDepartment of Translational Medicine and for Romagna, University of Ferrara, Ferrara 44121, Italy.
Lorenzo GardiniDepartment of Surgical Sciences, Unit of Ophthalmology, Ospedale Maggiore, Bologna 40100, Italy.
Luigi FontanaDepartment of Surgical Sciences, Ophthalmology Unit, Alma Mater Studiorum University of Bologna, IRCCS Azienda Ospedaliero-Universitaria Bologna, Bologna 40100, Italy.
Mutali MusaDepartment of Optometry, University of Benin, Benin 300283, Nigeria.
Caterina GaglianoDepartment of Medicine and Surgery, University of Enna "Kore", Enna 9410, Italy.
Marco ZeppieriDepartment of Ophthalmology, University Hospital of Udine, Udine 33100, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Retinal pigment epithelium (RPE) dysfunction is involved in the advancement of numerous degenerative retinal illnesses, such as age-related macular degeneration and hereditary retinal abnormalities. Transplantation of RPE produced from stem cells has emerged as a promising therapeutic strategy to restore retinal function and prevent vision loss. However, other obstacles impede its clinical application, including immunological rejection, cell viability, functional integration, and the necessity for consistent differentiation techniques. This review offers a thorough examination of the molecular processes regulating RPE integrity, investigates recent progress in stem cell-derived RPE therapeutics, and addresses significant challenges to their broad implementation. Furthermore, we emphasize prospective avenues intended to enhance the safety, efficacy, and enduring success of RPE transplantation in clinical environments.

Indexed as

Cell transplantationMolecular stem cell mechanismsRetinal degenerationRetinal pigment epitheliumStem cell therapy

Identifiers

PMID40503367
PMCPMC12149799

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.