Evidence map›Paper›PMID 40503366›Full record

ArticleWorld journal of stem cells2025

Collagen III combined with autologous adipose-derived mesenchymal stem cells accelerates burn wound healing in a rat model.

Xiao-Long Zhou, Ben Wu, Zi-Jing Xie, Hong-De Li

Abstract read
In one paragraph

Article in World journal of stem cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiao-Long ZhouHunan Provincial Key Laboratory of the Traditional Chinese Medicine Agricultural Biogenomics, College of Pharmacy, Changsha Medical University, Changsha 410219, Hunan Province, China.
Ben WuCollege of Pharmacy, Changsha Medical University, Changsha 410219, Hunan Province, China.
Zi-Jing XieHunan Provincial University Key Laboratory of the Regional Characteristic Traditional Chinese Medicine Resources and Ecological Agriculture, College of Pharmacy, Changsha Medical University, Changsha 410219, Hunan Province, China.
Hong-De LiHunan Provincial University Key Laboratory of the Fundamental and Clinical Research on Functional Nucleic Acid, College of Laboratory Medicine, Changsha Medical University, Changsha 410219, Hunan Province, China. azbyccx@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSkin is the largest organ in the human body and plays crucial roles in human health. Efficient and rapid healing of burn wounds is of great significance. While stem cell therapies have offered potential methods to treat burn wounds, relatively few have had success in clinical practice.

aimTo investigate the effect of the combined application of collagen III and adipose-derived stem cells (ASCs) on vascular regeneration in skin wound healing.

methodsBurn wounds were created in 18 adult male Sprague-Dawley rats, and they were randomly divided into two groups. In the treatment group, each rat was injected with 4 × 10

resultsMultiple injections of autologous ASCs improved wound closure rate more efficiently compared to the control group. Moreover, autologous ASCs do not survive long-term during the skin wound healing process.

conclusionThis study demonstrated that multiple injections of autologous ASCs combined with collagen III accelerated burn wound healing by increasing collagen deposition and improving angiogenesis.

Indexed as

Adipose-derived mesenchymal stem cellsAutologous transplantationCollagen IIISkin wound healingStem cell therapy

Identifiers

PMID40503366
PMCPMC12149801

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.