ReviewHealth science reports2025
The Efficacy of Hyaluronic Acid in Reducing Pelvic Adhesions in Patients Undergoing Gynecologic Laparoscopic Surgery: A Meta-Analysis of Randomized Clinical Trials.
Review in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: Intraperitoneal adhesions are a common complication after gynecologic surgery, leading to infertility, chronic pelvic pain, bowel obstruction, and surgical complications. Hyaluronic acid gel functions as a physical barrier, potentially reducing the formation of postoperative adhesions by minimizing tissue contact during the healing process. Methods: A comprehensive search was carried out across PubMed, the Cochrane Library, Scopus, Embase, and http://ClinicalTrials.gov from their inception until July 2023 to locate randomized controlled trials (RCTs) assessing the effectiveness of hyaluronic acid gel in preventing pelvic adhesions following gynecologic surgery. Eligible studies were required to be RCTs with reported clinical outcomes related to adhesion formation and published in English. Two reviewers independently screened the studies, extracted the relevant data, and evaluated methodological quality using the Jadad scoring system. For the statistical analysis, dichotomous variables were analyzed using risk ratios (RR), while continuous outcomes were summarized using standardized mean differences (SMD). Between-study heterogeneity was examined using the Results: Hyaluronic acid gel significantly reduced moderate adhesions (RR: 0.32; 95% CI: 0.20-0.45) and overall adhesion severity (SMD: -1.31; 95% CI: -1.99 to -0.62). The severe adhesion score also decreased (SMD: -0.65; 95% CI: -0.91 to -0.40), but the reduction in severe adhesions was not statistically significant (RR: 0.77; 95% CI: 0.47-1.24). Conclusion: Hyaluronic acid gel serves as an effective physical barrier to prevent the formation of pelvic adhesions in women undergoing gynecological surgery. While its role in reducing severe adhesions was not statistically significant, it demonstrated a significant reduction in moderate adhesions and overall adhesion severity. Trial Registration: Protocol registered in PROSPERO (CRD42023429293).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.