ArticleHealth science reports2025
A Cross-Sectional Study of Platelet-to-Lymphocyte Ratio in Relation to Pigment Cell Nevi and Atypical Mole Syndrome.
Article in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: Melanocytic nevi (MN) and atypical melanocytic nevi (AMN) are established risk factors for cutaneous malignant melanoma (CMM), with patients exhibiting atypical mole syndrome (AMS) facing an even greater risk. Peripheral blood biomarkers-including neutrophil-to-lymphocyte ratio (NLR), eosinophil-to-lymphocyte ratio (ELR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII)-have been linked to various cancers, including CMM. This cross-sectional study aimed to investigate the relationship between these biomarkers and MN and AMS, which are common phenotypes among melanoma patients. Methods: A total of 505 subjects (aged 21-79, 254 males and 249 females, 96 with immunosuppression) at elevated risk of any type of skin cancer were examined for MN, AMN, level of cutaneous photodamage, and other potential confounding factors. A peripheral blood sample was analyzed for blood cells. Results: PLR levels were significantly higher in subjects with more than 50 nevi or AMS. In multivariable logistic regression models, high PLR was significantly associated with having more than 50 melanocytic nevi (OR: 2.015, 95% CI: 1.159-3.501, Conclusion: This study demonstrates a statistically significant association between elevated PLR and the presence of more than 50 MN or AMS, whereas no associations were observed with NLR, ELR, or SII. This specific relationship suggests that PLR may have particular relevance in the context of multiple MN and AMS, potentially influencing its interpretation in melanoma prognosis. However, further studies are needed to validate this finding, explore underlying biological mechanisms, and assess causality.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.