Evidence map›Paper›PMID 40503314›Full record

ArticleRSC advances2025

Galactose receptor-mediated hepatic targeting system: engineering of quinary cationic liposomes for resveratrol delivery against hepatic steatosis.

Zhijie Liang, Jinzhuai Li, Shuying Luo, Shaorong Li, Kun Zhao, Hongmian Jiang, Yisi Ou, Juan Zhong, Lifeng Luo, Huali Huang and 1 more

Abstract read
In one paragraph

Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhijie LiangResearch Institute of Lanzhou University in Shenzhen Shenzhen 518000 China.
Jinzhuai LiState Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University Guilin 541004 China.
Shuying LuoMedical Experimental Center, The Fifth Affiliated Hospital of Guangxi Medical University Nanning 530000 China hualihuang999@126.com.
Shaorong LiMedical Experimental Center, The Fifth Affiliated Hospital of Guangxi Medical University Nanning 530000 China hualihuang999@126.com.
Kun ZhaoDepartments of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University Nanning 530021 China.
Hongmian JiangMedical Experimental Center, The Fifth Affiliated Hospital of Guangxi Medical University Nanning 530000 China hualihuang999@126.com.ORCID https://orcid.org/0009-0002-1534-9486
Yisi OuDepartment of Traditional Chinese Medicine, The Reproduction Hospital of Guangxi Zhuang Autonomous Region Nanning 530000 China lyynaturemed@163.com.
Juan ZhongMedical Experimental Center, The Fifth Affiliated Hospital of Guangxi Medical University Nanning 530000 China hualihuang999@126.com.
Lifeng LuoMedical Experimental Center, The Fifth Affiliated Hospital of Guangxi Medical University Nanning 530000 China hualihuang999@126.com.
Huali HuangMedical Experimental Center, The Fifth Affiliated Hospital of Guangxi Medical University Nanning 530000 China hualihuang999@126.com.
Yingying LiDepartment of Traditional Chinese Medicine, The Reproduction Hospital of Guangxi Zhuang Autonomous Region Nanning 530000 China lyynaturemed@163.com.ORCID https://orcid.org/0009-0008-6735-0298

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Resveratrol (RSV), a natural polyphenol with potent antioxidant and anti-inflammatory properties, exhibits significant therapeutic potential for non-alcoholic fatty liver disease (NAFLD) by modulating lipid metabolism, oxidative stress, and inflammatory pathways. Despite its multi-target mechanisms and enhancement of reverse cholesterol transport, clinical translation remains limited by poor bioavailability and inefficient intracellular delivery. Conventional oral administration fails to achieve therapeutic plasma concentrations owing to extensive first-pass metabolism and low solubility. To address these limitations, this study developed galactose (Gal)-modified lipid nanoparticles (Gal-LNPs) to enhance hepatic targeting

Identifiers

PMID40503314
PMCPMC12153050

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.