ArticleHIV/AIDS (Auckland, N.Z.)2025
The Usefulness of Mediastinal Cryobiopsy in the Diagnosis of Mediastinal Lymphadenopathy in HIV Patients.
Article in HIV/AIDS (Auckland, N.Z.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Diagnosis of Microscopic Polyangiitis by EBUS-Guided Transbronchial Mediastinal Cryobiopsy: A Case Report.Diagnostics (Basel, Switzerland) · 2026Article
- Diagnostic nomogram based on ultrasound and clinical data of predicting malignant lymph nodes in HIV patients with lymphadenopathy.Frontiers in cellular and infection microbiology · 2025Article
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5 authors.
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Abstract
Introduction: Mediastinal diseases in HIV patients show complex diagnostic challenges due to opportunistic infections and rare neoplasms. While Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a key technique, its effectiveness is limited as it only provides cytological samples. Endobronchial ultrasound-guided mediastinal cryobiopsy (CryoEBUS) emerges as a promising alternative, yielding larger and higher-quality samples. This study, the first in Mexico and the first worldwide in HIV patients, evaluates its diagnostic efficacy compared to EBUS-TBNA, highlighting its potential to improve disease management in immunocompromised populations. Materials and Methods: A prospective cross-sectional study has been conducted from April 2023 to October 2023 at a tertiary center for respiratory diseases in Mexico, evaluating the usefulness of the endobronchial ultrasound-guided mediastinal cryobiopsy (CryoEBUS) diagnostic in HIV-positive patients with mediastinal lymphadenopathy ≥1cm. Patients underwent CryoEBUS, with outcomes assessed via pathology and microbiology reports. Results: Eleven patients were included (64% male, mean age 39.1 years). CryoEBUS yielded diagnostic results in 82% of cases compared to 72% for bronchoalveolar lavage (BAL) and 50% for EBUS alone. Combined CryoEBUS and BAL demonstrated the highest yield (91%). Conclusion: In patients with HIV and mediastinal lymphadenopathy, mediastinal cryobiopsy has proven to be a useful, effective technique with a high diagnostic yield, especially for benign pathologies. It has also proven to be a safe technique and when combined with other lung sampling techniques, it improves the diagnostic yield of infectious diseases and rare neoplasms.
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