Evidence map›Paper›PMID 40503232›Full record

ArticleFrontiers in immunology2025

Exploring the role of neutrophils in inflammatory pain hypersensitivity via single-cell transcriptome profiling.

Kai Ding, Xing Liu, Bin Zeng, Songyu Liu, Lu Zhang, Bo Li, Jinyi Zhou, Xiaosan Su, Jun Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kai DingDepartment of Anesthesiology, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Xing LiuDepartment of Anesthesiology, The Affiliated Yan'an Hospital of Kunming Medical University, Kunming, China.
Bin ZengDepartment of Anesthesiology, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Songyu LiuSchool of Basic Medical Sciences, Yunnan University of Chinese Medicine, Kunming, China.
Lu ZhangSchool of Basic Medical Sciences, Yunnan University of Chinese Medicine, Kunming, China.
Bo LiDepartment of Neurosurgery, The Third Affiliated Hospital of Kunming Medical University, Kunming, China.
Jinyi ZhouDepartment of Neurosurgery, The Third Affiliated Hospital of Kunming Medical University, Kunming, China.
Xiaosan SuScientific Research and Experimental Center, Yunnan University of Chinese Medicine, Kunming, China.
Jun WangDepartment of Anesthesiology, The First Affiliated Hospital of Kunming Medical University, Kunming, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Myeloid CD11b Methods: scRNA-seq was used to analyze the transcriptomes of CD11b Results: scRNA-seq revealed a significant increase in neutrophils and a decrease in monocytes among CD11b Discussion: Following surgery and CFA treatment, mature neutrophils were significantly elevated. The CXCR2 antagonist NAMO alleviated post-surgical and CFA-induced pain by inhibiting neutrophil differentiation and maturation. These findings offer novel approaches for pain prevention and treatment.

Indexed as

InflammationNeutrophilsTranscriptomeAnimalsCD11b AntigenCell DifferentiationDisease Models, AnimalGene Expression ProfilingMaleMiceMice, Inbred C57BLReceptors, Interleukin-8BSingle-Cell AnalysisCD11b AntigenReceptors, Interleukin-8BCXCR2inflammationNAMOneutrophilpain

Identifiers

PMID40503232
PMCPMC12151834

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.