Evidence map›Paper›PMID 40503088›Full record

ArticleMayo Clinic proceedings. Innovations, quality & outcomes2025

A Randomized Trial of At-Home COVID-19 Tests, Telemedicine, and Rapid Prescription Delivery for Immunocompromised Individuals.

Julia Moore Vogel, Ting-Yang Hung, Erin Coughlin, Felipe Delgado, Vik Kheterpal, Giorgio Quer, Eric Topol

Registry-linked trialAbstract read
In one paragraph

Article in Mayo Clinic proceedings. Innovations, quality & outcomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05655546 (ImmunoCARE), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05655546 naterminatednot on this map

ImmunoCARE: Rapid, Accurate COVID Testing to Reduce Hospitalization of Immunocompromised Individuals

TypeinterventionalSponsorScripps Translational Science InstituteRan2022 to 2024Enrolled2,117ConditionsImmunodeficiency, Immunosuppression, HIV Infections, Graft Versus Host DiseaseArmsAccess to Cue Health COVID-19 Remote testing and treatment for COVID-19
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Julia Moore VogelScripps Research Translational Institute, Scripps Research, La Jolla, CA.
Ting-Yang HungScripps Research Translational Institute, Scripps Research, La Jolla, CA.
Erin CoughlinScripps Research Translational Institute, Scripps Research, La Jolla, CA.
Felipe DelgadoScripps Research Translational Institute, Scripps Research, La Jolla, CA.
Vik KheterpalCareEvolution, Ann Arbor, MI.
Giorgio QuerScripps Research Translational Institute, Scripps Research, La Jolla, CA.
Eric TopolScripps Research Translational Institute, Scripps Research, La Jolla, CA.

Funding

Scripps Clinical and Translational Science HubUM1TR004407 · NCATS · SCRIPPS RESEARCH INSTITUTE, THE · PI Eric Jeffrey Topol · 2023 to 2026
$24.2M
NCATS NIH HHS UM1 TR004407
6 · The paper itself

Abstract

Objective: To evaluate whether access to at-home COVID-19 tests, telemedicine, and same-day prescription delivery could reduce COVID cases, hospitalizations, and the cost of COVID care for the high-risk populations using a randomized controlled trial. Patients and Methods: Individuals participated remotely between December 1, 2022, and May 16, 2024, with half (n=346, 51.5%) receiving the option to access 10 at-home COVID-19 tests per month for themselves and others in their household as well as telemedicine and same-day Paxlovid delivery, and half (n=325, 48.4%) following their standard testing and treatment practices. Outcome data were collected from surveys, electronic health records and claims. Results: Intensive care unit admissions were significantly reduced for intervention participants vs control participants (0.3% vs 4.6%, n=1 vs 13; Conclusion: In immunocompromised individuals and those at least aged 65 years, access to at-home COVID tests, telemedicine, and rapid Paxlovid delivery reduced the severity of COVID-19 infections, as reflected by a reduced need for intensive care unit admissions; this has the potential to reduce the cost of COVID care. Trial Registration: clinicaltrials.gov Identifier: NCT05655546.

Identifiers

PMID40503088
PMCPMC12152619

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.