ArticleClinical, cosmetic and investigational dermatology2025
Association Between Serum Uric Acid Levels and Skin Cancer: Results from NHANES Data and Mendelian Randomization Analysis.
Article in Clinical, cosmetic and investigational dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Non-linear association between preoperative uric acid levels and female thyroid cancer risk.Discover oncology · 2026Article
- Ultra-High-Frequency Ultrasound of Melanoma Excision Scars for Detection of Clinically Occult Local Recurrence: A Single-Center Retrospective Study.Clinical, cosmetic and investigational dermatology · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Previous studies have suggested that serum uric acid (SUA), a byproduct of purine metabolism, may be associated with cancer development. However, the relationship between SUA levels and skin cancers-malignant melanoma (MM) and non-melanoma skin cancer (NMSC)-remains poorly understood. The main purpose of this study is to investigate the relationship between serum uric acid levels and the risk of malignant melanoma and non-melanoma skin cancer. Patients and Methods: This research examined NHANES data (1999-2020) to explore the association between serum uric acid levels and skin cancer risk in a cohort of 1219 patients (336 mm cases and 883 NMSC cases). Using Mendelian randomization (IVW as primary method, MR-Egger and weighted median as secondary approaches), GWAS data evaluated causality. Sensitivity tests were conducted to ensure the robustness of the findings, while RCS models were used to analyze nonlinear exposure-outcome relationships. Multivariable regression models were employed to adjust for age, sex, race, lifestyle, and comorbidities, thereby isolating the independent effect of serum uric acid. Results: High serum uric acid (SUA) levels are strongly linked to increased risks of MM and NMSC, particularly in women and Mexican American populations. Risk trends vary at different SUA thresholds, and elevated levels are tied to other negative health outcomes. However, no causal relationship between SUA levels and skin cancer has been established. Conclusion: This study addresses gaps in prior research by revealing a significant association between high serum uric acid (SUA) levels and increased risks of both malignant melanoma (MM) and non-melanoma skin cancer (NMSC). Notably, SUA may serve as a valuable biomarker for risk assessment, particularly among women and Mexican Americans. Even so, further research is needed to better understand the biological mechanisms underlying SUA's role in skin cancer development.
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