ArticleNAR genomics and bioinformatics2025
Enhancing R-loop prediction with high-throughput sequencing data.
Article in NAR genomics and bioinformatics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The role of R-loops-mediated epigenetic regulation in genome stability maintenance and disease pathogenesis: a systematic review.Epigenetics · 2026Pooled it
- In silico mapping of non-canonical DNA structures across the human ribosomal DNA locus.G3 (Bethesda, Md.) · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
R-loops are three-stranded RNA and DNA hybrid structures that often occur in the genome and play important roles in a variety of cellular processes from bacteria to mammals. Sequencing methods profiling R-loops genome-wide have revealed that they can form co-transcriptionally at cell type specific genes and associate with specific chromatin states during cell differentiation and reprogramming. However, current computational methods for the prediction of R-loops rely solely on their DNA sequence properties, which precludes detection across cell types, tissues or developmental stages. Here, we conduct a machine learning approach that allows the prediction of mammalian cell type-specific R-loops using sequence information and high-throughput sequencing signals. Our predictive models are induced from human samples and achieve highly accurate predictions, with transcriptomics, DNA features, chromatin accessibility and the active gene body H3K36me3 epigenomic mark being the most informative datasets. We generate
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.