ReviewJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences2025
Diagnostic value of circular RNAs as promising hematological biomarkers in acute myeloid leukemia: A systematic review and meta-analysis.
Review in Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Beyond the DNA sequence: mapping the dynamic epigenetic landscape for risk stratification and therapeutic intervention in acute myeloid leukemia.Clinical and experimental medicine · 2025Review
- Assessing the prognostic value of long non-coding RNAs in glioblastoma patients: findings from a systematic review and meta-analysis.Cancer cell international · 2025Review
- MiR-15a-5p, c-MYB, and circHIPK3 Axis as a Potential Diagnostic and Clinicopathological-Related Network in Acute Myeloid Leukemia.Advanced biomedical research · 2025Article
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Authors and funding
4 authors.
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Abstract
Despite significant advancements in the diagnosis and treatment of acute myeloid leukemia (AML), patients still face poor diagnosis with unsatisfactory survival, so it is imperative to explore novel diagnostic biomarkers to improve early detection and treatment outcomes. Thus, here, the potential role of circular RNAs (circRNAs) in AML diagnosis is reviewed. PubMed, Scopus, WOS, ProQuest databases, and Google Scholar search engines were searched for studies published through March 2023. The results were assessed using the modified method of GRADE assessment. The sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the summary receiver operating characteristic curve (AUC) were combined to investigate the diagnostic role of circRNAs in AML. The number of studies included in this systematic review and meta-analysis was 18. For the diagnostic value of circRNAs in AML, the pooled SEN, SPE, PLR, and NLR were 0.85 (95% confidence interval [CI]: 0.80-0.89), 0.85 (95% CI: 0.82-0.88), 5.74 (95% CI: 4.49-7.33), and 0.18 (95% CI: 0.13-0.24), respectively. Furthermore, the pooled DOR and AUC were 32.71 (95% CI: 20.09-53.24) and 0.91 (95% CI: 0.88-0.93), respectively. Furthermore, through subgroup analysis, it is better to have a sample size above 120 and a control/patient ratio above 50%. In addition, Deek's funnel plot demonstrated nonconsiderable publication bias (
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