ArticleOncology letters2025
Overexpression of decorin gene influences the biological behaviors of follicular thyroid carcinoma cells.
Article in Oncology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Global burden of cancer attributable to high BMI (1990-2031): a multidimensional analysis based on GBD and Mendelian randomization.Frontiers in nutrition · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of the present study was to examine the impact of decorin (DCN) gene overexpression on the proliferation, migration and invasion of human follicular thyroid carcinoma (FTC) cells. DCN expression was evaluated by western blotting (WB) in Nthy-ori3-1 normal thyroid cells and in two FTC cell lines, namely FTC-133 and FTC-238. Lentiviral transfection was employed to overexpress DCN in the FTC cells, with the overexpression efficiency confirmed through reverse transcription-quantitative polymerase chain reaction and WB. Cell viability, colony formation, wound healing and Transwell invasion assays were conducted to assess the proliferation, migration and invasion of the transfected cells. The results revealed that DCN expression in FTC-133 and FTC-238 cells was significantly lower compared with that in Nthy-ori3-1 cells. Successful lentiviral overexpression of DCN in the FTC cell lines significantly decreased the proliferation and colony formation abilities of the cells, and diminished their wound healing and invasive capabilities. This indicated that the lentivirus-mediated overexpression of DCN in FTC-133 and FTC-238 cells altered their cellular behavior, providing experimental evidence to support the suggestion that DCN is a potential therapeutic target for FTC.
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