Evidence map›Paper›PMID 40503026›Full record

ArticleArXiv2025

A cautious user's guide in applying HMMs to physical systems.

M Schweiger, A Saurabh, S Pressé

Abstract readPreprint
In one paragraph

Article in ArXiv, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

M SchweigerDepartment of Physics, Arizona State University, Tempe, AZ, USA.
A SaurabhDepartment of Physics, Arizona State University, Tempe, AZ, USA.
S PresséDepartment of Physics, Arizona State University, Tempe, AZ, USA.

Funding

Scalable 3D molecular imaging and data analysis for cell census generationRF1MH128867 · NIMH · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI PRESSE, STEVE, SHEPHERD, DOUGLAS · 2021 to 2021
$2.2M
Toward high spatiotemporal resolution models of single molecules for in vivo applicationsR35GM148237 · NIGMS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI Steve Presse · 2023 to 2026
$1.7M
A Bayesian nonparametric approach to superresolved tracking of multiple molecules inside living cellsR01GM130745 · NIGMS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI PRESSE, STEVE · 2019 to 2023
$1.5M
Theoretical Models of Single Molecule Dynamics from Minimal Photon NumbersR01GM134426 · NIGMS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI PRESSE, STEVE · 2019 to 2022
$1.2M
NIGMS NIH HHS R01 GM130745NIGMS NIH HHS R01 GM134426NIGMS NIH HHS R35 GM148237NIMH NIH HHS RF1 MH128867
6 · The paper itself

Abstract

Nature, as far as we know, evolves continuously through space and time. Yet the ubiquitous hidden Markov model (HMM)-originally developed for discrete time and space analysis in natural language processing-remains a central tool in interpreting time series data drawn from from physical systems. This raises a fundamental question: What are the implications of applying a discrete-state, discrete-time framework to analyze data generated by a continuously evolving system? Through synthetic data generated using Langevin dynamics in an effective potential, we explore under what circumstances HMMs yield interpretable results. Our analysis reveals that the discrete-state approximation acts primarily as an abstraction with the inferred states visited in time often more closely reflecting the measurement protocol and modeling choices than features of the underlying physical potential. Crucially, we demonstrate that the states visited over the course of a time series recovered by the HMM can be tuned

Identifiers

PMID40503026
PMCPMC12155118

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.