Evidence map›Paper›PMID 40503011›Full record

ArticleMolecular therapy. Methods & clinical development2025

Comparison of NSG-Quad and MISTRG-6 humanized mice for modeling circulating and tumor-infiltrating human myeloid cells.

Anna Chen, Viktoria Knöbl, Oliver Walzer, Jana Hauser, Ines Neuwirth, Magdalena Frank, Nina Braun, Semina Duvnjak, Johannes Reisecker, Carmen Stecher and 3 more

Abstract read
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. IL-9R/Arg1 pathway promotes polyamine metabolism in human airway macrophages.The Journal of allergy and clinical immunology · 2026
    Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anna ChenCenter for Cancer Research, Medical University of Vienna and Comprehensive Cancer Center, 1090 Vienna, Austria.
Viktoria KnöblDepartment of General Surgery, Division of Vascular Surgery, Medical University of Vienna, 1090 Vienna, Austria.
Oliver WalzerCenter for Cancer Research, Medical University of Vienna and Comprehensive Cancer Center, 1090 Vienna, Austria.
Jana HauserCenter for Cancer Research, Medical University of Vienna and Comprehensive Cancer Center, 1090 Vienna, Austria.
Ines NeuwirthCenter for Cancer Research, Medical University of Vienna and Comprehensive Cancer Center, 1090 Vienna, Austria.
Magdalena FrankCenter for Cancer Research, Medical University of Vienna and Comprehensive Cancer Center, 1090 Vienna, Austria.
Nina BraunCenter for Cancer Research, Medical University of Vienna and Comprehensive Cancer Center, 1090 Vienna, Austria.
Semina DuvnjakCenter for Cancer Research, Medical University of Vienna and Comprehensive Cancer Center, 1090 Vienna, Austria.
Johannes ReiseckerCenter for Cancer Research, Medical University of Vienna and Comprehensive Cancer Center, 1090 Vienna, Austria.
Carmen StecherCenter for Cancer Research, Medical University of Vienna and Comprehensive Cancer Center, 1090 Vienna, Austria.
Alex FarrDepartment of Obstetrics and Gynecology, Division of Obstetrics and Feto-Maternal Medicine, Medical University of Vienna and Comprehensive Center for Pediatrics (CCP), Medical University of Vienna, 1090 Vienna, Austria.
Christine BrostjanDepartment of General Surgery, Division of Vascular Surgery, Medical University of Vienna, 1090 Vienna, Austria.
Dietmar Herndler-BrandstetterCenter for Cancer Research, Medical University of Vienna and Comprehensive Cancer Center, 1090 Vienna, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Humanized mice are valuable preclinical models for immuno-oncology research because they allow modeling of human immune cells and human tumors

Indexed as

colorectal cancerhuman immune system miceimmuno-oncologyMISTRG-6NSG-Quadtumor microenvironmenttumor xenograft

Identifiers

PMID40503011
PMCPMC12152875

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.