Evidence map›Paper›PMID 40502983›Full record

ArticleGastroenterology report2025

Association of maternal smoking, breastfeeding, and multiple birth with irritable bowel syndrome in older adults: a UK Biobank cohort study.

Xinyang Liu, Ruilang Lin, Xinyue Li, Mengjiang He, Yanbo Liu, Jianwei Hu, Weifeng Chen, Quanlin Li, Yongfu Yu, Pinghong Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gastroenterology report, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xinyang LiuEndoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Ruilang LinDepartment of Biostatistics, School of Public Health, and The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, P. R. China.
Xinyue LiEndoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Mengjiang HeEndoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Yanbo LiuEndoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Jianwei HuEndoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Weifeng ChenEndoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Quanlin LiEndoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Yongfu YuDepartment of Biostatistics, School of Public Health, and The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, P. R. China.ORCID https://orcid.org/0000-0003-4208-9480
Pinghong ZhouEndoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.ORCID https://orcid.org/0000-0002-5434-0540

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: We aimed to investigate associations between three perinatal early-life factors and the risk of irritable bowel syndrome (IBS) in middle-aged and elderly people by using data from UK Biobank. Methods: This is a population-based cohort study. Participants who had available data on early-life factors-namely maternal smoking around birth, being breastfed as a baby, and being one of a multiple birth and without IBS at the time of recruitment in UK Biobank-were included. Results: Among a total of 334,586 subjects, 93,908 (28.07%) were exposed to maternal smoking around birth, 243,778 (72.86%) were breastfed as a baby, and 7,551 (2.26%) were part of a multiple birth. During a median follow-up of 13.58 years, 7,254 participants developed IBS, at a median age of 63 years. The hazard ratios of IBS were 1.22 [95% confidence interval (CI), 1.16-1.28, Conclusions: Participants exposed to maternal smoking around birth and being one of a multiple birth had a higher risk of IBS in middle-aged and elderly stages, while being breastfed as a baby had a protective effect against IBS. Future efforts should be made to validate the results.

Indexed as

irritable bowel syndromeperinatal early-life factorsTownsend Deprivation IndexUK Biobank

Identifiers

PMID40502983
PMCPMC12158159

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.