Evidence map›Paper›PMID 40502976›Full record

ArticleACS catalysis2025

Organometallic Catalysis Catches up with Enzymatic in the Regeneration of NADH.

Caterina Trotta, Giuseppe Fraschini, Elena Tacchi, Leonardo Tensi, Cristiano Zuccaccia, Gabriel Menendez Rodriguez, Alceo Macchioni

Abstract read
In one paragraph

Article in ACS catalysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Selective Iridium-Catalyzed Reductive Amination Inside Living Cells.Journal of the American Chemical Society · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Caterina TrottaDepartment of Chemistry, Biology and Biotechnology and CIRCC, University of Perugia, Via Elce di sotto 8, Perugia 06123, Italy.
Giuseppe FraschiniDepartment of Chemistry, Biology and Biotechnology and CIRCC, University of Perugia, Via Elce di sotto 8, Perugia 06123, Italy.
Elena TacchiDepartment of Chemical Sciences, University of Padova, Via Marzolo 1, Padova 35131, Italy.
Leonardo TensiDepartment of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, Perugia 06123, Italy.ORCID https://orcid.org/0000-0002-0966-6859
Cristiano ZuccacciaDepartment of Chemistry, Biology and Biotechnology and CIRCC, University of Perugia, Via Elce di sotto 8, Perugia 06123, Italy.ORCID https://orcid.org/0000-0002-9835-2818
Gabriel Menendez RodriguezDepartment of Chemistry, Biology and Biotechnology and CIRCC, University of Perugia, Via Elce di sotto 8, Perugia 06123, Italy.ORCID https://orcid.org/0000-0003-2793-7760
Alceo MacchioniDepartment of Chemistry, Biology and Biotechnology and CIRCC, University of Perugia, Via Elce di sotto 8, Perugia 06123, Italy.ORCID https://orcid.org/0000-0001-7866-8332

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A rational design, based on a deep understanding of the reaction mechanism, led to the development of an iridium organometallic catalyst with activity comparable to that of enzymes in the chemical regeneration of NADH, using phosphite as a reducing agent. The innovative structural elements were individuated in replacing pyridine with pyrazine and adding a carbohydrazide moiety in the bidentate amidate supporting ligand. Resulting [Cp*Ir-(pyza-NH

Indexed as

iridium catalystsNADH regenerationNMRorganometallic chemistryX-ray diffractometry

Identifiers

PMID40502976
PMCPMC12150521

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.