Evidence map›Paper›PMID 40502814›Full record

ArticleMedComm2025

Superior Diagnostic Efficacy of N-Terminal Propeptide of Type III Collagen and Golgi Protein 73 for Detection of Fibrosis in Chronic Hepatitis B Patients.

Qianqian Chen, Ming-Hua Zheng, Li Zhu, Fajuan Rui, Wenjing Ni, Yali Xiong, Xinyu Hu, Rahma Issa, Yixuan Zhu, Leyao Jia and 6 more

Abstract read
In one paragraph

Article in MedComm, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Qianqian ChenDepartment of Infectious Diseases Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine Nanjing Jiangsu China.
Ming-Hua ZhengMAFLD Research Center Department of Hepatology the First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang China.ORCID https://orcid.org/0000-0003-4984-2631
Li ZhuDepartment of Hepatology the Fifth People's Hospital of Suzhou Suzhou Jiangsu China.ORCID https://orcid.org/0000-0002-0953-5912
Fajuan RuiDepartment of Infectious Diseases Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine Nanjing Jiangsu China.
Wenjing NiDepartment of Infectious Diseases Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine Nanjing Jiangsu China.
Yali XiongDepartment of Infectious Disease Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing Jiangsu China.
Xinyu HuDepartment of Infectious Disease Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing Jiangsu China.
Rahma IssaDepartment of Infectious Disease Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing Jiangsu China.
Yixuan ZhuDepartment of Infectious Disease Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing Jiangsu China.
Leyao JiaDepartment of Infectious Diseases Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University Nanjing Jiangsu China.
Scott BarnettDivision of Gastroenterology and Hepatology Stanford University Medical Center Palo Alto California USA.
Shengxia YinDepartment of Infectious Disease Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing Jiangsu China.
Chuanwu ZhuDepartment of Hepatology the Fifth People's Hospital of Suzhou Suzhou Jiangsu China.
Chao WuDepartment of Infectious Disease Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing Jiangsu China.
Mindie H NguyenDivision of Gastroenterology and Hepatology Stanford University Medical Center Palo Alto California USA.
Jie LiDepartment of Infectious Diseases Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine Nanjing Jiangsu China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Significant liver fibrosis is an indication for antiviral therapy in chronic hepatitis B (CHB). Using liver histology assessed by Scheuer system, we evaluated the diagnostic performance of PRO-C3, GP73, and their combination for the presence of liver fibrosis, and compared them with FIB-4, APRI, Agile 3+, FAST, and LSM in treatment-naïve CHB patients from two centers. The study included 324 patients, of whom 167 had S2-4 (significant fibrosis) and 83 had S3-4 (advanced fibrosis). PRO-C3 levels were higher in those with S2-4 and S3-4 compared with S0-1 and S0-2 (both

Indexed as

biomarkerchronic hepatitis BGolgi protein 73liver fibrosisN‐terminal propeptide of type III collagen

Identifiers

PMID40502814
PMCPMC12152426

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.