Evidence map›Paper›PMID 40502807›Full record

ReviewEpilepsy currents

How Can Animal Models Advance Research into High Frequency Oscillations: Guidelines for Recording, Detection and Analysis.

Christos Panagiotis Lisgaras, Richard J Staba, Liset M de la Prida

Abstract readReview
In one paragraph

Review in Epilepsy currents. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Christos Panagiotis LisgarasDepartment of Psychiatry, New York University Grossman School of Medicine, New York, NY, USA.ORCID https://orcid.org/0000-0003-3712-5993
Richard J StabaDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0003-2285-5627
Liset M de la PridaInstituto Cajal CSIC, Madrid, Spain.ORCID https://orcid.org/0000-0002-0160-6472

Funding

Translational Platform for Epilepsy Therapy and Biomarker DiscoveryR01NS127524 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Denes V. Agoston, LISA D COLES · 2022 to 2026
$11.0M
Defining the Epileptogenic Network and Identifying Which Components Generate SeizuresR01NS106957 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Richard Staba · 2018 to 2026
$3.4M
High frequency oscillations in Alzheimer's diseaseR21AG086880 · NIA · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI LISGARAS, CHRISTOS PANAGIOTIS · 2024 to 2024
$454k
NIA NIH HHS R21 AG086880NINDS NIH HHS R01 NS106957NINDS NIH HHS R01 NS127524
6 · The paper itself

Abstract

High frequency oscillations (HFOs) are being incorporated into the presurgical evaluation of patients with epilepsy and also represent a rapidly evolving field in basic epilepsy research. Animal models have been pivotal in uncovering the mechanisms underlying HFOs and their role in epilepsy. In this review, we provide an overview of HFOs recorded in animal models, highlighting their relevance not only to epilepsy but also to neuropsychiatric and Alzheimer's diseases, suggesting a broader role in brain disorders. Then we explore recent advances, including innovative computational methods for the automated detection and analysis of HFOs. Building on this analysis, we propose guidelines for HFO identification and reporting with translational potential from animal models to humans. Finally, we discuss existing knowledge gaps and outline future directions for research in this rapidly evolving field.

Indexed as

biomarkersclinical trialsinterictalsurgery

Identifiers

PMID40502807
PMCPMC12149158

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.