ArticleResearch square2025
Unique lipid cargoes in APOE4 human brain-derived extracellular vesicles recruit cell adhesion molecules and promote tauopathy in Alzheimer's disease.
Tsuneya Ikezu, Zhengrong Zhang, Kaiwen Yu, Hanmei Bao, Tadafumi Ikezu, Arun Reddy Ravula, Bridgette Melvin, Clara Scholes, Yang You, Justice Ellison and 7 more
Abstract readPreprint
In one paragraphArticle in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
17 authors.
Zhengrong ZhangMayo Clinic Florida.
Hanmei BaoUniversity of Texas Health Science Center at San Antonio.
Tadafumi IkezuMayo Clinic.
Arun Reddy RavulaMayo Clinic Florida.
Bridgette MelvinMayo Clinic Florida.
Clara ScholesUniversit of Manchester.
Justice EllisonMayo Clinic Florida.
Michael DeTureDepartment of Neuroscience, Mayo Clinic, Jacksonville, Florida.
Dennis DicksonMayo Clinic Florida.
Seiko IkezuMayo Clinic Florida.
Funding
Technology and Remote Assessment CoreU19AG063911 · NIA · MAYO CLINIC ROCHESTER · PI KEJAL KANTARCI · 2019 to 2026
$120.9MExosome-mediated propagation of pathogenic tau proteinRF1AG054199 · NIA · MAYO CLINIC JACKSONVILLE · PI IKEZU, TSUNEYA · 2016 to 2021
$5.0MTargeting the miR-155 and APOE-TREM2 pathways to restore dysfunctional microglia in Alzheimer’s diseaseR01AG054672 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI BUTOVSKY, OLEG, IKEZU, TSUNEYA · 2017 to 2021
$4.1MMolecular characterization of extracellular vesicles for the spread of misfolded tau proteinR01AG067763 · NIA · MAYO CLINIC JACKSONVILLE · PI IKEZU, TSUNEYA · 2021 to 2025
$3.1MAssessment of a novel tau propagation pathway from layer II medial entorhinal cortical neurons to CA1 pyramidal neurons as an early Braak stage mouse modelR01AG072719 · NIA · MAYO CLINIC JACKSONVILLE · PI IKEZU, TSUNEYA · 2021 to 2025
$2.7MTherapeutic evaluation of targeting Tau Tubulin kinase-1 in Alzheimer’s diseaseR01AG079859 · NIA · MAYO CLINIC JACKSONVILLE · PI Seiko Ikezu · 2023 to 2026
$2.2MTargeting emerging P2RX7 signaling pathways in animal models of Alzheimer's diseaseR01AG066429 · NIA · MAYO CLINIC JACKSONVILLE · PI IKEZU, TSUNEYA · 2020 to 2024
$2.0MNIA NIH HHS R01 AG054672NIA NIH HHS R01 AG066429NIA NIH HHS R01 AG067763NIA NIH HHS R01 AG072719NIA NIH HHS R01 AG079859NIA NIH HHS RF1 AG054199NIA NIH HHS U19 AG063911
6 · The paper itselfAbstract
Brain-derived extracellular vesicles (BDEVs) carry tau filaments and promote tau transmission in Alzheimer's disease (AD). However, how APOE ε4 allele, a key genetic risk factor for AD, may change BDEV molecular structures thereby facilitate disease progression is poorly understood. Here we report comprehensive analyses of BDEVs isolated from human E3/3 and E4/4 AD brains with a biological multi-omics approach. E4/4 BDEVs significantly enhanced tau propagation in aged human
Indexed as
Alzheimer’ Diseaseapolipoprotein Eextracellular vesiclesfree fatty acidshumanized animal modelsinduced pluripotent stem cellslipidomicsneural cell adhesion molecule 1proteomics
Identifiers
PMID40502793
PMCPMC12154133
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390